TY - JOUR
T1 - Repeated administration of amitriptyline reduces oxaliplatin-induced mechanical allodynia in rats
AU - Sada, Hikaru
AU - Egashira, Nobuaki
AU - Ushio, Soichiro
AU - Kawashiri, Takehiro
AU - Shirahama, Masafumi
AU - Oishi, Ryozo
PY - 2011
Y1 - 2011
N2 - Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes acute and chronic neuropathies in patients. Amitriptyline has widely been used in patients with painful neuropathy. In this study, we investigated the effect of amitriptyline on the oxaliplatin-induced neuropathy in rats. Repeated administration of amitriptyline (5 and 10 mg/kg, p.o., once a day) reduced the oxaliplatin-induced mechanical allodynia but not cold hyperalgesia and reversed the oxaliplatin-induced increase in the expression of NR2B protein and mRNA in rat spinal cord. These results suggest that amitriptyline is useful for the treatment of oxaliplatin-induced neuropathy clinically.
AB - Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes acute and chronic neuropathies in patients. Amitriptyline has widely been used in patients with painful neuropathy. In this study, we investigated the effect of amitriptyline on the oxaliplatin-induced neuropathy in rats. Repeated administration of amitriptyline (5 and 10 mg/kg, p.o., once a day) reduced the oxaliplatin-induced mechanical allodynia but not cold hyperalgesia and reversed the oxaliplatin-induced increase in the expression of NR2B protein and mRNA in rat spinal cord. These results suggest that amitriptyline is useful for the treatment of oxaliplatin-induced neuropathy clinically.
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U2 - 10.1254/jphs.12006SC
DO - 10.1254/jphs.12006SC
M3 - Article
C2 - 22466962
AN - SCOPUS:84867217574
SN - 1347-8613
VL - 118
SP - 547
EP - 551
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 4
ER -
