Removal of organic solvent from antibiotics with supercritical carbon dioxide

Masamichi Kamihira, Masayuki Taniguchi, Takeshi Kobayashi

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Organic solvents were rapidly extracted from penicillin G potassium and streptomycin sulfate with supercritical carbon dioxide (SC-CO2) at 200 atm and 35°C without loss of antibiotic activities. The amounts of organic solvents remaining in the antibiotics depended upon pressure and temperature for a given extraction time. A semilogarithmic plot of remaining amounts of organic solvents against extraction time gave a straight line in the early extraction stage, allowing prediction of the extraction time required for decreasing amounts of organic solvent. The addition of water as an entrainer to SC-CO2 resulted in a significant increase in extraction rates.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalJournal of Fermentation Technology
Issue number1
Publication statusPublished - 1987
Externally publishedYes


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