Remarkable enantioselectivity of molecularly imprinted TiO2 nano-thin films

Naoki Mizutani, Do Hyeon Yang, Roman Selyanchyn, Sergiy Korposh, Seung Woo Lee, Toyoki Kunitake

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


TiO2 nano-thin films with imprinted (R)- and (S)-enantiomers of propranolol, 1,1′-bi-naphthol, and 2-(4-isobutylphenyl)-propionic acid were fabricated on quartz plates by spin-coating their solutions with Ti(O-nBu)4 in a toluene-ethanol mixture (1:1, v/v). After template removal, the imprinted films showed better binding for original templates than to the corresponding enantiomers. The assessment of template incorporation, template removal, and re-binding was conducted through UV-vis measurements. Significant enhancement of enantioselectivity was achieved by optimization of the film thickness and by heat-treatment of the imprinted films. After subtraction of non-specific binding, the optimized films provided chiral recognition with the enantioselectivity of almost 100% for (R)-propranolol and 95% for (S)-propranolol.

Original languageEnglish
Pages (from-to)142-150
Number of pages9
JournalAnalytica Chimica Acta
Issue number1-2
Publication statusPublished - May 23 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy


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