TY - JOUR
T1 - Remarkable enantioselectivity of molecularly imprinted TiO2 nano-thin films
AU - Mizutani, Naoki
AU - Yang, Do Hyeon
AU - Selyanchyn, Roman
AU - Korposh, Sergiy
AU - Lee, Seung Woo
AU - Kunitake, Toyoki
N1 - Funding Information:
This work was supported by the Regional Innovation Cluster Program of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
PY - 2011/5/23
Y1 - 2011/5/23
N2 - TiO2 nano-thin films with imprinted (R)- and (S)-enantiomers of propranolol, 1,1′-bi-naphthol, and 2-(4-isobutylphenyl)-propionic acid were fabricated on quartz plates by spin-coating their solutions with Ti(O-nBu)4 in a toluene-ethanol mixture (1:1, v/v). After template removal, the imprinted films showed better binding for original templates than to the corresponding enantiomers. The assessment of template incorporation, template removal, and re-binding was conducted through UV-vis measurements. Significant enhancement of enantioselectivity was achieved by optimization of the film thickness and by heat-treatment of the imprinted films. After subtraction of non-specific binding, the optimized films provided chiral recognition with the enantioselectivity of almost 100% for (R)-propranolol and 95% for (S)-propranolol.
AB - TiO2 nano-thin films with imprinted (R)- and (S)-enantiomers of propranolol, 1,1′-bi-naphthol, and 2-(4-isobutylphenyl)-propionic acid were fabricated on quartz plates by spin-coating their solutions with Ti(O-nBu)4 in a toluene-ethanol mixture (1:1, v/v). After template removal, the imprinted films showed better binding for original templates than to the corresponding enantiomers. The assessment of template incorporation, template removal, and re-binding was conducted through UV-vis measurements. Significant enhancement of enantioselectivity was achieved by optimization of the film thickness and by heat-treatment of the imprinted films. After subtraction of non-specific binding, the optimized films provided chiral recognition with the enantioselectivity of almost 100% for (R)-propranolol and 95% for (S)-propranolol.
UR - http://www.scopus.com/inward/record.url?scp=79955741588&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955741588&partnerID=8YFLogxK
U2 - 10.1016/j.aca.2011.02.042
DO - 10.1016/j.aca.2011.02.042
M3 - Article
C2 - 21565315
AN - SCOPUS:79955741588
SN - 0003-2670
VL - 694
SP - 142
EP - 150
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
IS - 1-2
ER -