Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients

Shinya Matsumoto; Manabu Akahane; Yoshiyuki Kanagawa; Jumboku Kajiwara; Kiyomi Tsukimori; Norio Wake; Chikage Mitoma; Hiroshi Uchi; Masutaka Furue; Tomoaki Imamura

Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients

Shinya Matsumoto, Manabu Akahane, Yoshiyuki Kanagawa, Jumboku Kajiwara, Kiyomi Tsukimori, Norio Wake, Chikage Mitoma, Hiroshi Uchi, Masutaka Furue, Tomoaki Imamura

Research output: Contribution to journal › Article › peer-review

Abstract

Half-lives of blood levels of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) are varied in Yusho patients. The objective was to evaluate a relationship between half-lives of PeCDF levels and types of SNP rs10249788 of aryl hydrocarbon receptor (AHR) gene in 93 Yusho patients. Based on physical symptoms, age, sex, body mass index and other factors, we set up suitable calculation formulas to fit the actual PeCDF levels thorough rates of change in PeCDF. We found that patients with C/T SNP had longer half lives than patients with C/C and T/T SNPs. Patients with T/T SNP are known to express higher amount of AHR mRNAs. However, detailed analysis could not be carried out in T/T group due to a limited number of patients (n = 11). Further research is warranted to determine the cause of the longer half-lives in C/T patients.

Original language	English
Pages (from-to)	139-143
Number of pages	5
Journal	Fukuoka igaku zasshi = Hukuoka acta medica
Volume	106
Issue number	5
Publication status	Published - May 1 2015

All Science Journal Classification (ASJC) codes

Medicine(all)

Cite this

@article{123b9f92a29b448582876f0477ae2a9c,

title = "Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients",

abstract = "Half-lives of blood levels of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) are varied in Yusho patients. The objective was to evaluate a relationship between half-lives of PeCDF levels and types of SNP rs10249788 of aryl hydrocarbon receptor (AHR) gene in 93 Yusho patients. Based on physical symptoms, age, sex, body mass index and other factors, we set up suitable calculation formulas to fit the actual PeCDF levels thorough rates of change in PeCDF. We found that patients with C/T SNP had longer half lives than patients with C/C and T/T SNPs. Patients with T/T SNP are known to express higher amount of AHR mRNAs. However, detailed analysis could not be carried out in T/T group due to a limited number of patients (n = 11). Further research is warranted to determine the cause of the longer half-lives in C/T patients.",

author = "Shinya Matsumoto and Manabu Akahane and Yoshiyuki Kanagawa and Jumboku Kajiwara and Kiyomi Tsukimori and Norio Wake and Chikage Mitoma and Hiroshi Uchi and Masutaka Furue and Tomoaki Imamura",

year = "2015",

month = may,

day = "1",

language = "English",

volume = "106",

pages = "139--143",

journal = "Fukuoka igaku zasshi = Hukuoka acta medica",

issn = "0016-254X",

publisher = "福岡医学会",

number = "5",

}

TY - JOUR

T1 - Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients

AU - Matsumoto, Shinya

AU - Akahane, Manabu

AU - Kanagawa, Yoshiyuki

AU - Kajiwara, Jumboku

AU - Tsukimori, Kiyomi

AU - Wake, Norio

AU - Mitoma, Chikage

AU - Uchi, Hiroshi

AU - Furue, Masutaka

AU - Imamura, Tomoaki

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Half-lives of blood levels of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) are varied in Yusho patients. The objective was to evaluate a relationship between half-lives of PeCDF levels and types of SNP rs10249788 of aryl hydrocarbon receptor (AHR) gene in 93 Yusho patients. Based on physical symptoms, age, sex, body mass index and other factors, we set up suitable calculation formulas to fit the actual PeCDF levels thorough rates of change in PeCDF. We found that patients with C/T SNP had longer half lives than patients with C/C and T/T SNPs. Patients with T/T SNP are known to express higher amount of AHR mRNAs. However, detailed analysis could not be carried out in T/T group due to a limited number of patients (n = 11). Further research is warranted to determine the cause of the longer half-lives in C/T patients.

AB - Half-lives of blood levels of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) are varied in Yusho patients. The objective was to evaluate a relationship between half-lives of PeCDF levels and types of SNP rs10249788 of aryl hydrocarbon receptor (AHR) gene in 93 Yusho patients. Based on physical symptoms, age, sex, body mass index and other factors, we set up suitable calculation formulas to fit the actual PeCDF levels thorough rates of change in PeCDF. We found that patients with C/T SNP had longer half lives than patients with C/C and T/T SNPs. Patients with T/T SNP are known to express higher amount of AHR mRNAs. However, detailed analysis could not be carried out in T/T group due to a limited number of patients (n = 11). Further research is warranted to determine the cause of the longer half-lives in C/T patients.

UR - http://www.scopus.com/inward/record.url?scp=84940976039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940976039&partnerID=8YFLogxK

M3 - Article

C2 - 26226675

AN - SCOPUS:84940976039

SN - 0016-254X

VL - 106

SP - 139

EP - 143

JO - Fukuoka igaku zasshi = Hukuoka acta medica

JF - Fukuoka igaku zasshi = Hukuoka acta medica

IS - 5

ER -

Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients

Abstract

All Science Journal Classification (ASJC) codes

Other files and links

Fingerprint

Cite this