Abstract
The delayed footpad reaction against syngeneic testicular cells was studied in cyclophosphamide (CY)-pretreated mice whose mononuclear phagocyte system (MPS) was blocked with colloidal carbon or stimulated with Corynebacterium parvum (C. parvum). The delayed footpad reaction was augmented by MPS-blockade, whereas it was depressed by MPS-stimulation. It was observed that syngeneic testicular cells were phagocytized and degraded more effectively by C. parvum-stimulated macrophages in vitro and that the testicular antigen phagocytized by C. parvum-stimulated macrophages proved to become less immunogenic in cell transfer experiments.
| Original language | English |
|---|---|
| Pages (from-to) | 141-146 |
| Number of pages | 6 |
| Journal | Journal of Clinical and Laboratory Immunology |
| Volume | 7 |
| Issue number | 2 |
| Publication status | Published - 1982 |
All Science Journal Classification (ASJC) codes
- Immunology