Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells

Hiroshi Takane; Shigehiro Ohdo; Tomoko Yamada; Satoru Koyanagi; Eiji Yukawa; Shun Higuchi

doi:10.1016/S0024-3205(01)00943-2

Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells

Hiroshi Takane, Shigehiro Ohdo, Tomoko Yamada, Satoru Koyanagi, Eiji Yukawa, Shun Higuchi

Pharmaceutical Health Care and Sciences Faculty

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Whether the diurnal rhythm of cell cycle is associated with that of interferon-α/β receptor (IFNAR) expression was investigated in implanted-tumor cells. The expression of IFNAR mRNA significantly increased when the proportion of tumor cells in DNA synthesis (S) phase increased in vitro. A diurnal rhythm was observed for cell cycle distribution in implanted-tumor cells. The specific binding of interferon-α to receptor and IFNAR mRNA increased when the proportion of tumor cells in S phase increased in vivo. The time-dependent expression of IFNAR was supported by that of transcription factor level induced by interferon-β. The present result suggests that the rhythm of IFNAR expression is closely related to that of cell cycle distribution in implanted-tumor cells.

Original language	English
Pages (from-to)	1449-1455
Number of pages	7
Journal	Life Sciences
Volume	68
Issue number	12
DOIs	https://doi.org/10.1016/S0024-3205(01)00943-2
Publication status	Published - Feb 9 2001

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1016/S0024-3205(01)00943-2

Cite this

@article{1f5574b654d34f0ab344b1a71a524bc7,

title = "Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells",

abstract = "Whether the diurnal rhythm of cell cycle is associated with that of interferon-α/β receptor (IFNAR) expression was investigated in implanted-tumor cells. The expression of IFNAR mRNA significantly increased when the proportion of tumor cells in DNA synthesis (S) phase increased in vitro. A diurnal rhythm was observed for cell cycle distribution in implanted-tumor cells. The specific binding of interferon-α to receptor and IFNAR mRNA increased when the proportion of tumor cells in S phase increased in vivo. The time-dependent expression of IFNAR was supported by that of transcription factor level induced by interferon-β. The present result suggests that the rhythm of IFNAR expression is closely related to that of cell cycle distribution in implanted-tumor cells.",

author = "Hiroshi Takane and Shigehiro Ohdo and Tomoko Yamada and Satoru Koyanagi and Eiji Yukawa and Shun Higuchi",

note = "Funding Information: This research was supported by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science, Sports and Culture, Japan (S.O., 00223884). We are indebted to Toray Industries Inc. (Tokyo, Japan) for providing interferon-β (Feron{\textregistered}) used in this study.",

year = "2001",

month = feb,

day = "9",

doi = "10.1016/S0024-3205(01)00943-2",

language = "English",

volume = "68",

pages = "1449--1455",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "12",

}

TY - JOUR

T1 - Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells

AU - Takane, Hiroshi

AU - Ohdo, Shigehiro

AU - Yamada, Tomoko

AU - Koyanagi, Satoru

AU - Yukawa, Eiji

AU - Higuchi, Shun

N1 - Funding Information: This research was supported by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science, Sports and Culture, Japan (S.O., 00223884). We are indebted to Toray Industries Inc. (Tokyo, Japan) for providing interferon-β (Feron®) used in this study.

PY - 2001/2/9

Y1 - 2001/2/9

N2 - Whether the diurnal rhythm of cell cycle is associated with that of interferon-α/β receptor (IFNAR) expression was investigated in implanted-tumor cells. The expression of IFNAR mRNA significantly increased when the proportion of tumor cells in DNA synthesis (S) phase increased in vitro. A diurnal rhythm was observed for cell cycle distribution in implanted-tumor cells. The specific binding of interferon-α to receptor and IFNAR mRNA increased when the proportion of tumor cells in S phase increased in vivo. The time-dependent expression of IFNAR was supported by that of transcription factor level induced by interferon-β. The present result suggests that the rhythm of IFNAR expression is closely related to that of cell cycle distribution in implanted-tumor cells.

AB - Whether the diurnal rhythm of cell cycle is associated with that of interferon-α/β receptor (IFNAR) expression was investigated in implanted-tumor cells. The expression of IFNAR mRNA significantly increased when the proportion of tumor cells in DNA synthesis (S) phase increased in vitro. A diurnal rhythm was observed for cell cycle distribution in implanted-tumor cells. The specific binding of interferon-α to receptor and IFNAR mRNA increased when the proportion of tumor cells in S phase increased in vivo. The time-dependent expression of IFNAR was supported by that of transcription factor level induced by interferon-β. The present result suggests that the rhythm of IFNAR expression is closely related to that of cell cycle distribution in implanted-tumor cells.

UR - http://www.scopus.com/inward/record.url?scp=0035830576&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035830576&partnerID=8YFLogxK

U2 - 10.1016/S0024-3205(01)00943-2

DO - 10.1016/S0024-3205(01)00943-2

M3 - Article

C2 - 11388696

AN - SCOPUS:0035830576

SN - 0024-3205

VL - 68

SP - 1449

EP - 1455

JO - Life Sciences

JF - Life Sciences

IS - 12

ER -

Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this