Relapsed non-Hodgkin's lymphoma: Detection and treatment

Yoshiyuki Shioyama, Katsumasa Nakamura, Naonobu Kunitake, Masahiko Kimura, Hiromi Terashima, Kouji Masuda

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Purpose: To evaluate the optimal management strategy during clinical remission and after relapse in patients with non-Hodgkin's lymphoma (NHL). Methods: Sixty-six patients with relapse of NHL from a state of clinical remission between 1987 and 1997 were analyzed retrospectively. The pattern of relapses, diagnostic methods used for relapses, and clinical outcome of salvage treatment were analyzed with attention to time after the achievement of clinical remission. Results: Thirty-three relapses (50%) occurred within 12 months, and the remainder occurred gradually from 12-48 months after the first remission. Diagnosis of relapse in 61 of the 66 patients (93%) was made at unscheduled evaluations prompted by symptoms, on physical examinations, or because of high LDH levels. The 1- and 5-year cause-specific survival rates after relapse were 56.7% and 39.4%, respectively. The 1- and 5-year relapse-free survival rates were 50.1% and 35.0%, respectively. The 5-year relapse-free survival rate in patients with late relapse (49.5%) was significantly better than in those with early relapse (21.2%) (p<0.01). Conclusion: Time to relapse may be a useful factor to determine optimal management strategy in NHL patients.

Original languageEnglish
Pages (from-to)369-375
Number of pages7
JournalRadiation Medicine - Medical Imaging and Radiation Oncology
Issue number6
Publication statusPublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Oncology


Dive into the research topics of 'Relapsed non-Hodgkin's lymphoma: Detection and treatment'. Together they form a unique fingerprint.

Cite this