Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3

Sakae Tanaka, Hidetoshi Wakeyama, Toru Akiyama, Katsuhiko Takahashi, Hitoshi Amano, Keiichi I. Nakayama, Kozo Nakamura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

17 Citations (Scopus)


Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.

Original languageEnglish
Title of host publicationOsteoimmunology
Subtitle of host publicationInteractions of the Immune and Skeletal Systems II
EditorsYongwon Choi
Number of pages6
Publication statusPublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology


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