Regulation of cardiovascular TRP channel functions along the NO-cGMP-PKG axis

Ryuji Inoue, Juan Shi, Zhong Jian, Yuko Imai

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


There is growing body of evidence that nitric oxide (NO)-cGMP-PKG signaling plays a central role in negative regulation of cardiovascular (CV) responses and its disorders through suppressed Ca2+ dynamics. Other lines of evidence also reveal the stimulatory effects of this signaling on some CV functions. Recently, transient receptor potential (TRP) channels have received much attention as non-voltage-gated Ca2+ channels involved in CV physiology and pathophysiology. Available information suggests that these channels undergo both inhibition and activation by NO via PKG-mediated phosphorylation and S-nitrosylation, respectively, and also act as upstream regulators to promote endothelial NO production. This review summarizes the roles of NO-cGMP-PKG signaling pathway, particularly in regulating TRP channel functions with their associated physiology and pathophysiology.

Original languageEnglish
Pages (from-to)347-360
Number of pages14
JournalExpert Review of Clinical Pharmacology
Issue number3
Publication statusPublished - May 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)


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