TY - JOUR
T1 - Regulation of body temperature by thyrotropin-releasing hormone in neonatal chicks
AU - Takahashi, Hirokazu
AU - Iigo, Masayuki
AU - Ando, Kôichi
AU - Tachibana, Tetsuya
AU - Denbow, D. Michael
AU - Furuse, Mitsuhiro
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science.
PY - 2005/6/9
Y1 - 2005/6/9
N2 - To understand thermal regulation of neonatal chicks, the contribution of thyrotropin-releasing hormone (TRH), a key regulator of the hypothalamus- pituitary-thyroid axis, was investigated. Intracerebroventricular (i.c.v.) injection of TRH (5 and 20 μg) increased body temperature, but did not change plasma T3 and T4 concentrations. Intraperitoneal (i.p.) injection of triiodothyronine (T3) and thyroxine (T4) did not influence body temperature. Thereafter, the relationships between TRH and the hypothalamus-pituitary-adrenal axis and sympathetic nervous system were further investigated. Central TRH stimulated both corticosterone and epinephrine release. The i.c.v. injection of a corticotropin-releasing factor receptor antagonist attenuated the change in body temperature and corticosterone concentration caused by TRH, but did not influence plasma T3 and T4 concentrations. The i.p. injection of epinephrine did not induce hyperthermia. Therefore, the thermoregulatory response to TRH may differ in neonatal stages being dependent upon the stimulation of the hypothalamus- pituitary-adrenal axis rather than the hypothalamus-pituitary-thyroid axis.
AB - To understand thermal regulation of neonatal chicks, the contribution of thyrotropin-releasing hormone (TRH), a key regulator of the hypothalamus- pituitary-thyroid axis, was investigated. Intracerebroventricular (i.c.v.) injection of TRH (5 and 20 μg) increased body temperature, but did not change plasma T3 and T4 concentrations. Intraperitoneal (i.p.) injection of triiodothyronine (T3) and thyroxine (T4) did not influence body temperature. Thereafter, the relationships between TRH and the hypothalamus-pituitary-adrenal axis and sympathetic nervous system were further investigated. Central TRH stimulated both corticosterone and epinephrine release. The i.c.v. injection of a corticotropin-releasing factor receptor antagonist attenuated the change in body temperature and corticosterone concentration caused by TRH, but did not influence plasma T3 and T4 concentrations. The i.p. injection of epinephrine did not induce hyperthermia. Therefore, the thermoregulatory response to TRH may differ in neonatal stages being dependent upon the stimulation of the hypothalamus- pituitary-adrenal axis rather than the hypothalamus-pituitary-thyroid axis.
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U2 - 10.1016/j.devbrainres.2005.03.004
DO - 10.1016/j.devbrainres.2005.03.004
M3 - Article
C2 - 15939085
AN - SCOPUS:20444496105
SN - 0165-3806
VL - 157
SP - 58
EP - 64
JO - Developmental Brain Research
JF - Developmental Brain Research
IS - 1
ER -