TY - JOUR
T1 - Regulation of Biomolecular-Motor-Driven Cargo Transport by Microtubules under Mechanical Stress
AU - Nasrin, Syeda Rubaiya
AU - Afrin, Tanjina
AU - Kabir, Arif Md Rashedul
AU - Inoue, Daisuke
AU - Torisawa, Takayuki
AU - Oiwa, Kazuhiro
AU - Sada, Kazuki
AU - Kakugo, Akira
N1 - Funding Information:
This work was financially supported by a Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area) to A.K. (JSPS KAKENHI Grant Number JP18H05423), a Grant-in-Aid for Young Scientists (B) to A.M.R.K. (JSPS KAKENHI Grant Number JP16K16383) from the Japan Society for the Promotion of Science (JSPS) and a research grant from Hirose International Scholarship Foundation to A. M. R. K. (PK22181027).
Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020
Y1 - 2020
N2 - Mechanical stress on cells has profound influences on biological processes, such as cell shape regulation, the formation of tissue patterns, and development. Recently, mechanosensing properties of the microtubule, an important cytoskeletal component, have drawn attention. In this work, we studied cargo transport by dynein, a microtubule-associated motor protein, along microtubules deformed under mechanical stress. We reveal that the microtubule deformation took place as a response to the applied stress and that the deformation of microtubules facilitated the transport of dynein-driven quantum dots. This finding will provide opportunities to explore the role of microtubules as molecular mechanotransducers in cellular processes.
AB - Mechanical stress on cells has profound influences on biological processes, such as cell shape regulation, the formation of tissue patterns, and development. Recently, mechanosensing properties of the microtubule, an important cytoskeletal component, have drawn attention. In this work, we studied cargo transport by dynein, a microtubule-associated motor protein, along microtubules deformed under mechanical stress. We reveal that the microtubule deformation took place as a response to the applied stress and that the deformation of microtubules facilitated the transport of dynein-driven quantum dots. This finding will provide opportunities to explore the role of microtubules as molecular mechanotransducers in cellular processes.
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U2 - 10.1021/acsabm.9b01010
DO - 10.1021/acsabm.9b01010
M3 - Article
C2 - 35025310
AN - SCOPUS:85081684974
SN - 1944-8244
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
ER -