Regulation of Biomolecular-Motor-Driven Cargo Transport by Microtubules under Mechanical Stress

Syeda Rubaiya Nasrin, Tanjina Afrin, Arif Md Rashedul Kabir, Daisuke Inoue, Takayuki Torisawa, Kazuhiro Oiwa, Kazuki Sada, Akira Kakugo

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Mechanical stress on cells has profound influences on biological processes, such as cell shape regulation, the formation of tissue patterns, and development. Recently, mechanosensing properties of the microtubule, an important cytoskeletal component, have drawn attention. In this work, we studied cargo transport by dynein, a microtubule-associated motor protein, along microtubules deformed under mechanical stress. We reveal that the microtubule deformation took place as a response to the applied stress and that the deformation of microtubules facilitated the transport of dynein-driven quantum dots. This finding will provide opportunities to explore the role of microtubules as molecular mechanotransducers in cellular processes.

Original languageEnglish
JournalACS Applied Materials and Interfaces
Publication statusAccepted/In press - 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)


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