Regulation of B-cell fate by antigen-receptor signals

Hiroaki Niiro, Edward A. Clark

Research output: Contribution to journalReview articlepeer-review

528 Citations (Scopus)


Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints during their development. Targeted disruption of BCR signalling components leads to distinct blocks in B-cell maturation, which indicates that key kinases and adaptors fine-tune BCR signalling to direct appropriate cell fates. Recent progress in unravelling the molecular mechanisms of the BCR signalling pathways has helped to clarify how BCR signals regulate the proliferation, survival and apoptosis of developing B cells.

Original languageEnglish
Pages (from-to)945-956
Number of pages12
JournalNature Reviews Immunology
Issue number12
Publication statusPublished - Dec 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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