Regulation of angiogenesis by growth factors

M. Kuwano, S. Ushiro, M. Ryuto, K. Samoto, H. Izumi, K. I. Ito, T. Abe, T. Nakamura, M. Ono, K. Kohno

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Normal angiogenesis is self-limiting and strictly regulated while tumor angiogenesis appears to be deregulated. Angiogenesis proceeds upon a balance of angiogenic factors and inhibitors, with which expression of plasminogen activator (PA) and its inhibitor is closely associated. Angiogenic factors such as fibroblast growth factors, epidermal growth factor/transforming growth factor (TGF)-α, and vascular endothelial growth factor induce cell migration, tubulogenesis, and PA. By contrast) anti-angiogenic factors such as TGF-β and tumor necrosis factor-α inhibit cell migration tubulogenesis and expression of PA. In this article, we discuss how such angiogenic factors and anti-angiogenic factors modulate angiogenesis in model systems.

Original languageEnglish
Pages (from-to)113-125
Number of pages13
JournalGann Monographs on Cancer Research
Publication statusPublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cancer Research


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