Registration between histopathological images with different stains and an MRI Image of pancreatic cancer tumor

Hidekata Hontani, Yushi Goto, Yuki Tamura, Tomoshige Shimomura, Naoki Kawamura, Hirokazu Kobayashi, Mauricio Kugler, Tatsuya Yokota, Chika Iwamoto, Kenoki Ohuchida, Makoto Hashizume, Takahiro Katagiri, Tomonari Sei, Akinobu Shimizu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)


In this paper, we report on the construction of a pancreatic tumor model that represents the relationship between the tumor growth and the micro anatomical structures. The former, the tumor growth, is described by referring to the temporal series of MRI images of the whole body and the latter, the micro structures of the tumor, is described by a spatial series of microscopic images of thin-sections sliced from the extracted pancreatic tumor. For the model construction, we developed new non-rigid registration methods for (1) accurate description of tumor growth, (2) reconstruction of 3D microscopic images, and (3) registration between an MRI image and corresponding microscopic images. In addition, we constructed a neural network that can generate a set of fake microscopic image patches of a pancreatic tumor that corresponds to each voxel inside the tumor region in an MRI image. The outlines of the methods are introduced and some examples of experimental results are demonstrated.

Original languageEnglish
Title of host publicationInternational Forum on Medical Imaging in Asia 2019
EditorsHiroshi Fujita, Jong Hyo Kim, Feng Lin
ISBN (Electronic)9781510627758
Publication statusPublished - 2019
EventInternational Forum on Medical Imaging in Asia 2019 - Singapore, Singapore
Duration: Jan 7 2019Jan 9 2019

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceInternational Forum on Medical Imaging in Asia 2019

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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