TY - JOUR
T1 - Regional cerebral glucose metabolism in patients with Parkinson's disease with or without dementia
AU - Sasaki, Masayuki
AU - Ichiya, Yuichi
AU - Hosokawa, Shinichi
AU - Otsuka, Makoto
AU - Kuwabara, Yasuo
AU - Fukumura, Toshimitsu
AU - Kato, Motohiro
AU - Goto, Ikuo
AU - Masuda, Kouji
PY - 1992/12
Y1 - 1992/12
N2 - By means of positron emission tomography, the cerebral glucose metabolism in 5 patients with Parkinson's disease with dementia was compared with that in 9 patients without dementia, and that in 5 normal volunteers. The metabolic rates for glucose were measured by placing one hundred regions of interest. In the demented patients, cerebral glucose metabolism was diffusely decreased compared with that of the non-demented patients and the normal controls. The most significant decrease in glucose metabolism was observed in the angular gyrus (49.7% of the normal controls). The glucose metabolism in the cingulate, pre- and postcentral, occipital and subcortical regions was relatively spared (62.1 to 85.5% of the normal controls). In the patients without dementia, the glucose metabolism in each region was not significantly different from that in the normal controls. These results suggest that diffuse glucose hypometabolism in the cerebral cortex may correlate with that of patients with Parkinson's disease with dementia.
AB - By means of positron emission tomography, the cerebral glucose metabolism in 5 patients with Parkinson's disease with dementia was compared with that in 9 patients without dementia, and that in 5 normal volunteers. The metabolic rates for glucose were measured by placing one hundred regions of interest. In the demented patients, cerebral glucose metabolism was diffusely decreased compared with that of the non-demented patients and the normal controls. The most significant decrease in glucose metabolism was observed in the angular gyrus (49.7% of the normal controls). The glucose metabolism in the cingulate, pre- and postcentral, occipital and subcortical regions was relatively spared (62.1 to 85.5% of the normal controls). In the patients without dementia, the glucose metabolism in each region was not significantly different from that in the normal controls. These results suggest that diffuse glucose hypometabolism in the cerebral cortex may correlate with that of patients with Parkinson's disease with dementia.
UR - http://www.scopus.com/inward/record.url?scp=0027059069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027059069&partnerID=8YFLogxK
U2 - 10.1007/BF03164661
DO - 10.1007/BF03164661
M3 - Article
C2 - 1489634
AN - SCOPUS:0027059069
SN - 0914-7187
VL - 6
SP - 241
EP - 246
JO - Annals of Nuclear Medicine
JF - Annals of Nuclear Medicine
IS - 4
ER -