Reflections on the state of diabetes research and prospects for treatment

Domenico Accili; Wen Du; Takumi Kitamoto; Taiyi Kuo; Wendy McKimpson; Yasutaka Miyachi; Maria Mukhanova; Jinsook Son; Liheng Wang; Hitoshi Watanabe

doi:10.1007/s13340-022-00600-2

Reflections on the state of diabetes research and prospects for treatment

Domenico Accili, Wen Du, Takumi Kitamoto, Taiyi Kuo, Wendy McKimpson, Yasutaka Miyachi, Maria Mukhanova, Jinsook Son, Liheng Wang, Hitoshi Watanabe

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Research on the etiology and treatment of diabetes has made substantial progress. As a result, several new classes of anti-diabetic drugs have been introduced in clinical practice. Nonetheless, the number of patients achieving glycemic control targets has not increased for the past 20 years. Two areas of unmet medical need are the restoration of insulin sensitivity and the reversal of pancreatic beta cell failure. In this review, we integrate research advances in transcriptional regulation of insulin action and pathophysiology of beta cell dedifferentiation with their potential impact on prospects of a durable “cure” for patients suffering from type 2 diabetes.

Original language	English
Pages (from-to)	21-31
Number of pages	11
Journal	Diabetology International
Volume	14
Issue number	1
DOIs	https://doi.org/10.1007/s13340-022-00600-2
Publication status	Published - Jan 2023
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13340-022-00600-2

Cite this

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title = "Reflections on the state of diabetes research and prospects for treatment",

abstract = "Research on the etiology and treatment of diabetes has made substantial progress. As a result, several new classes of anti-diabetic drugs have been introduced in clinical practice. Nonetheless, the number of patients achieving glycemic control targets has not increased for the past 20 years. Two areas of unmet medical need are the restoration of insulin sensitivity and the reversal of pancreatic beta cell failure. In this review, we integrate research advances in transcriptional regulation of insulin action and pathophysiology of beta cell dedifferentiation with their potential impact on prospects of a durable “cure” for patients suffering from type 2 diabetes.",

author = "Domenico Accili and Wen Du and Takumi Kitamoto and Taiyi Kuo and Wendy McKimpson and Yasutaka Miyachi and Maria Mukhanova and Jinsook Son and Liheng Wang and Hitoshi Watanabe",

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AU - Accili, Domenico

AU - Du, Wen

AU - Kitamoto, Takumi

AU - Kuo, Taiyi

AU - McKimpson, Wendy

AU - Miyachi, Yasutaka

AU - Mukhanova, Maria

AU - Son, Jinsook

AU - Wang, Liheng

AU - Watanabe, Hitoshi

PY - 2023/1

Y1 - 2023/1

N2 - Research on the etiology and treatment of diabetes has made substantial progress. As a result, several new classes of anti-diabetic drugs have been introduced in clinical practice. Nonetheless, the number of patients achieving glycemic control targets has not increased for the past 20 years. Two areas of unmet medical need are the restoration of insulin sensitivity and the reversal of pancreatic beta cell failure. In this review, we integrate research advances in transcriptional regulation of insulin action and pathophysiology of beta cell dedifferentiation with their potential impact on prospects of a durable “cure” for patients suffering from type 2 diabetes.

AB - Research on the etiology and treatment of diabetes has made substantial progress. As a result, several new classes of anti-diabetic drugs have been introduced in clinical practice. Nonetheless, the number of patients achieving glycemic control targets has not increased for the past 20 years. Two areas of unmet medical need are the restoration of insulin sensitivity and the reversal of pancreatic beta cell failure. In this review, we integrate research advances in transcriptional regulation of insulin action and pathophysiology of beta cell dedifferentiation with their potential impact on prospects of a durable “cure” for patients suffering from type 2 diabetes.

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Reflections on the state of diabetes research and prospects for treatment

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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