Reductive etherification under microfluidic conditions: Application to practical synthesis of the FGHIJ-ring system of yessotoxin

Reductive etherification, a key reaction for constructing the H-ring in the convergent synthesis of the FGHIJ-ring system of yessotoxin, was problematic because the yield dramatically decreased upon increasing the scale of the reaction. This issue was solved by the use of a microflow reactor, and a gram scale reaction was successfully performed.