TY - JOUR
T1 - Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver
AU - Iida, Shinya
AU - Kamiya, Hiroyuki
AU - Nakaya, Akihiro
AU - Hayashi, Yasuhiro
AU - Sawada, Akihiro
AU - Kaji, Noritada
AU - Baba, Yoshinobu
AU - Harashima, Hideyoshi
PY - 2013/12
Y1 - 2013/12
N2 - Expression of the asparagine synthetase gene is dependent on extracellular glucose concentration. This gene was knocked-down in livers of male Balb/c mice by a hydrodynamic tail vein injection of small interfering RNA (siRNA) against the gene. This knockdown resulted in a significant decrease in plasma glucose concentration. These results suggested that asparagine synthetase is a novel protein that regulates plasma glucose levels.
AB - Expression of the asparagine synthetase gene is dependent on extracellular glucose concentration. This gene was knocked-down in livers of male Balb/c mice by a hydrodynamic tail vein injection of small interfering RNA (siRNA) against the gene. This knockdown resulted in a significant decrease in plasma glucose concentration. These results suggested that asparagine synthetase is a novel protein that regulates plasma glucose levels.
UR - http://www.scopus.com/inward/record.url?scp=84892610298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892610298&partnerID=8YFLogxK
U2 - 10.1248/bpb.b13-00414
DO - 10.1248/bpb.b13-00414
M3 - Article
C2 - 24292060
AN - SCOPUS:84892610298
SN - 0918-6158
VL - 36
SP - 2009
EP - 2011
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
IS - 12
ER -