Recognition of DNA with assembly of minor groove binders mediated by metal complexation.

Tomonobu Kataoka; Mikimasa Tanada; Ippei Onishi; Shigeki Sasaki

doi:10.1093/nass/nrl080

Recognition of DNA with assembly of minor groove binders mediated by metal complexation.

Tomonobu Kataoka, Mikimasa Tanada, Ippei Onishi, Shigeki Sasaki

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Genome-targeting molecules would have broad application as probes in genomic study. We recently developed the ligands (Bpy-H) connecting the Hoechst33258 skeleton for DNA binding and 2,2'-bipyridine for Cu(2+) complexation. It was shown that L-Bpy-H with a long linker exhibited Cu(2+)-mediated assembly on the DNA template having two A(3)T(3) sites in a ratio of 1:2:1 DNA-ligand-Cu(2+). Binding selectivity depends on the distance between the two A(3)T(3) sites of DNA. In contrast, S-Bpy-H having a short linker tended to form 1:2:2 DNA-ligand-Cu(2+) complex.

Original language	English
Pages (from-to)	161-162
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	50
DOIs	https://doi.org/10.1093/nass/nrl080
Publication status	Published - 2006

All Science Journal Classification (ASJC) codes

Medicine(all)

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abstract = "Genome-targeting molecules would have broad application as probes in genomic study. We recently developed the ligands (Bpy-H) connecting the Hoechst33258 skeleton for DNA binding and 2,2'-bipyridine for Cu(2+) complexation. It was shown that L-Bpy-H with a long linker exhibited Cu(2+)-mediated assembly on the DNA template having two A(3)T(3) sites in a ratio of 1:2:1 DNA-ligand-Cu(2+). Binding selectivity depends on the distance between the two A(3)T(3) sites of DNA. In contrast, S-Bpy-H having a short linker tended to form 1:2:2 DNA-ligand-Cu(2+) complex.",

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AU - Kataoka, Tomonobu

AU - Tanada, Mikimasa

AU - Onishi, Ippei

AU - Sasaki, Shigeki

PY - 2006

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AB - Genome-targeting molecules would have broad application as probes in genomic study. We recently developed the ligands (Bpy-H) connecting the Hoechst33258 skeleton for DNA binding and 2,2'-bipyridine for Cu(2+) complexation. It was shown that L-Bpy-H with a long linker exhibited Cu(2+)-mediated assembly on the DNA template having two A(3)T(3) sites in a ratio of 1:2:1 DNA-ligand-Cu(2+). Binding selectivity depends on the distance between the two A(3)T(3) sites of DNA. In contrast, S-Bpy-H having a short linker tended to form 1:2:2 DNA-ligand-Cu(2+) complex.

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Recognition of DNA with assembly of minor groove binders mediated by metal complexation.

Abstract

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