Recent progress in understanding the mechanisms of Leydig cell differentiation

Miki Inoue, Takashi Baba, Ken ichirou Morohashi

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Leydig cells in fetal and adult testes play pivotal roles in eliciting male characteristics by producing androgen. Although numerous studies of Leydig cells have been performed, the mechanisms for differentiation of the two cell types (fetal Leydig and adult Leydig cells), their developmental and functional relationship, and their differential characteristics remain largely unclear. Based on recent technical progress in genome-wide analysis and in vitro investigation, novel and fascinating observations concerning the issues above have been obtained. Focusing on fetal and adult Leydig cells, this review summarizes the recent progress that has advanced our understanding of the cells.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalMolecular and Cellular Endocrinology
Publication statusPublished - Jun 15 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology


Dive into the research topics of 'Recent progress in understanding the mechanisms of Leydig cell differentiation'. Together they form a unique fingerprint.

Cite this