Recent advances in the pathogenesis of hyper IgE syndrome

Hidetoshi Takada, Yoshiyuki Minegishi

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Hyperimmunoglobulin-E syndrome (HIES) is one of the primary immunodeficiency with the manifestations of recurrent infections especially with Staphylococcus aureus, characteristic facies, hyperextensibility of joints, multiple bone fractures, scoliosis, and delayed shedding of the primary teeth. It is a multisystem disease of autosomal dominant or recessive inheritance. Recently, the genetic causes of HIES (STAT3, TYK2, and DOCK8) were clarified.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalJapanese Journal of Clinical Immunology
Issue number1
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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