Recent advances in preoperative hyperthermochemoradiotherapy for patients with esophageal cancer

Hiroshi Saeki, Hidetoshi Kawaguchi, Kaoru Kitamura, Shinji Ohno, Keizo Sugimachi

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25 Citations (Scopus)


Background and Objectives: Hyperthermochemoradiotherapy (HCR) has been performed on numerous patients with esophageal cancer. The purpose of this study is to demonstrate the recent advances in HCR. Methods: From 1965 to 1997, 294 patients given preoperative chemoradiotherapy (CR) or HCR were classified according to the anticancer agent that was administered (CR; group A given bleomycin (BLM); group B given cis-diamminedichloroplatinum (II) (CDDP), HCR; group C given BLM; and Group D given CDDP). The local response and the long-term results were investigated. Results: The cases in which CR or HCR was evaluated to be effective numbered 44 (48.4%) in group A, 22 (73.3%) in group B, 79 (63.7%) in group C, and 36 (73.5%) in group D. A significant difference was observed between groups A and B (P < 0.05). The highest incidence of markedly effective cases was observed in group D. The 5- year survival rates for the group A and B patients were 17.2% and 43.9%, respectively (P < 0.01), while the same rates for those of groups C and D were 25.6% and 57.8%, respectively (P < 0.05). Our results thus showed CDDP to have a greater effect than BLM, while HCR had a greater effect than CR. Conclusions: Preoperative HCR has improved thanks to recent advances in anticancer agents.

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalJournal of Surgical Oncology
Issue number4
Publication statusPublished - Dec 1 1998

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology


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