Randomized controlled study of felypressin-propitocaine and mepivacaine for inferior alveolar nerve block

Kentaro Ouchi, Katsuhisa Sunada

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2 Citations (Scopus)


Felypressin-propitocaine (FP) and mepivacaine (M) are marketed as local anesthetics that do not contain adrenaline. These anesthetics are frequently used for patients with circulatory diseases. However, differences of these anesthetics are not clear when used for inferior alveolar nerve block. The present randomized controlled trial sought to compare the effects of FP and M for inferior alveolar nerve blocks. The studied group consisted of 19 healthy volunteers. Using blocked randomization, the following two anesthetics was randomly assigned to perform inferior alveolar nerve blocks : FP group (1.6 ml) and M group (1.6 ml). The subjects were asked to assess anesthesia success rate (occurrence of lower lip anesthesia in less than 20 minutes), anesthetic onset, duration of anesthetic effect and the degree of discomfort associated with inferior alveolar nerve blocks. An electric pulp tester was used to evaluate the anesthetic effects on each tooth. Dental pulp was judged as being anesthetized if no response was observed after application of the maximum stimulus for up to 60 minutes after the drug was administered. Chronological changes in success rate of pulp anesthesia (cases of pulp anesthesia/total cases) were examined. The data obtained between the two groups were analyzed as follows. Anesthesia success rate, anesthetic onset and duration of anesthetic effect were analyzed by unpaired-t test. Chronological changes in success rate of pulp anesthesia were analyzed by chi-square test. The number of discomfort were analyzed by Mann-Whitney test. Statistical significance was considered when P values for the respective test were <0.05. Anesthesia success rate was not significantly different. Chronological changes in success rate of pulp anesthesia for FP group was significantly higher than M group by multiple points in time. They were 5-30 minutes value in lateral incisor, 5-10 minutes value in premolar, and 5, 15 and 30-50 minutes value in molar. However on other points in time, both groups had similar results (Fig. 1). Anesthesia onset was not significantly different between FP group and M group (Table 1). Duration of anesthetic effect in FP group was significantly longer than in the M group (Table 2). The number of discomfort with inferior alveolar nerve block was not significantly different (Table 3). These findings suggest that FP can be a potential candidate for a drug of choice when quick onset and long lasting anesthesia is desired.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalJournal of Japanese Dental Society of Anesthesiology
Issue number3
Publication statusPublished - 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Dentistry
  • Anesthesiology and Pain Medicine


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