Radiotherapy for early-stage primary ocular adnexal mucosa-associated lymphoid tissue lymphoma

Saiji Ohga, Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Tadamasa Yoshitake, Kazushige Atsumi, Kotaro Terashima, Kaori Asai, Keiji Matsumoto, Hiroshi Yoshikawa, Yo Ichi Kawano, Hiroshi Honda

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Background: Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (POAML) is a rare disease. The purpose of this study was to evaluate the treatment outcome and patterns of failure of patients with early-stage POAML treated with radiotherapy. Patients and Methods: From 1995 to 2008, 53 patients with early-stage POAML were reviewed. Tumors were categorized as either superficial or mass-forming type. In principle, superficial lesions (n=11) were treated with 24 Gy, while the mass-forming lesions (n=42) were irradiated with 30 Gy. The median follow-up period was 3.9 years. Results: All four cases of relapse had mass-forming lesions. The 5-year overall and progression-free survival rates were 100% and 91.5%, respectively. Although 30 patients experienced grade 2 or 3 late adverse events, no patients had radiation-related retinopathy. Conclusion: Early-stage POAML can be well-controlled with radiotherapy. However, the risk of distant relapse should be noted, in particular, for mass-forming tumors.

Original languageEnglish
Pages (from-to)5575-5578
Number of pages4
JournalAnticancer research
Issue number12
Publication statusPublished - Dec 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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