Radiological features of brain metastases from non-small cell lung cancer harboring EGFR mutation

Shinkichi Takamori; Gouji Toyokawa; Mototsugu Shimokawa; Fumihiko Kinoshita; Yuka Kozuma; Taichi Matsubara; Naoki Haratake; Takaki Akamine; Nobutaka Mukae; Fumihiko Hirai; Tetsuzo Tagawa; Yoshinao Oda; Toru Iwaki; Koji Iihara; Hiroshi Honda; Yoshihiko Maehara

doi:10.21873/anticanres.12653

Radiological features of brain metastases from non-small cell lung cancer harboring EGFR mutation

Shinkichi Takamori, Gouji Toyokawa, Mototsugu Shimokawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Nobutaka Mukae, Fumihiko Hirai, Tetsuzo Tagawa, Yoshinao Oda, Toru Iwaki, Koji Iihara, Hiroshi Honda, Yoshihiko Maehara

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Abstract

Aim: To investigate the radiological features on computed tomography (CT) of brain metastasis (BM) from epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). Patients and Methods: Thirty-four patients with NSCLC with BMs who underwent surgical resection of the BMs at the Department of Neurosurgery, Kyushu University from 2005 to 2016 were enrolled in the study. The EGFR statuses of the 34 BMs were investigated. Radiological features, including the number, size, and location of the tumor, were delineated by CT. Results: Patients with EGFR-mutated BMs had significantly higher frequencies of multiple metastases than those with the non-EGFR-mutated type (p=0.042). BMs harboring mutations in EGFR were more frequently observed in the central area of the brain compared to those without mutations in EGFR (p=0.037). Conclusion: Careful follow-up of patients with EGFR-mutated NSCLC may be necessary given the high frequencies of multiple BMs and their location in the central area of the brain.

Original language	English
Pages (from-to)	3731-3734
Number of pages	4
Journal	Anticancer research
Volume	38
Issue number	6
DOIs	https://doi.org/10.21873/anticanres.12653
Publication status	Published - Jun 2018

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.12653

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Takamori, S., Toyokawa, G., Shimokawa, M., Kinoshita, F., Kozuma, Y., Matsubara, T., Haratake, N., Akamine, T., Mukae, N., Hirai, F., Tagawa, T., Oda, Y., Iwaki, T., Iihara, K., Honda, H., & Maehara, Y. (2018). Radiological features of brain metastases from non-small cell lung cancer harboring EGFR mutation. Anticancer research, 38(6), 3731-3734. https://doi.org/10.21873/anticanres.12653

Takamori, S, Toyokawa, G, Shimokawa, M, Kinoshita, F, Kozuma, Y, Matsubara, T, Haratake, N, Akamine, T, Mukae, N, Hirai, F, Tagawa, T, Oda, Y, Iwaki, T, Iihara, K, Honda, H & Maehara, Y 2018, 'Radiological features of brain metastases from non-small cell lung cancer harboring EGFR mutation', Anticancer research, vol. 38, no. 6, pp. 3731-3734. https://doi.org/10.21873/anticanres.12653

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abstract = "Aim: To investigate the radiological features on computed tomography (CT) of brain metastasis (BM) from epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). Patients and Methods: Thirty-four patients with NSCLC with BMs who underwent surgical resection of the BMs at the Department of Neurosurgery, Kyushu University from 2005 to 2016 were enrolled in the study. The EGFR statuses of the 34 BMs were investigated. Radiological features, including the number, size, and location of the tumor, were delineated by CT. Results: Patients with EGFR-mutated BMs had significantly higher frequencies of multiple metastases than those with the non-EGFR-mutated type (p=0.042). BMs harboring mutations in EGFR were more frequently observed in the central area of the brain compared to those without mutations in EGFR (p=0.037). Conclusion: Careful follow-up of patients with EGFR-mutated NSCLC may be necessary given the high frequencies of multiple BMs and their location in the central area of the brain.",

author = "Shinkichi Takamori and Gouji Toyokawa and Mototsugu Shimokawa and Fumihiko Kinoshita and Yuka Kozuma and Taichi Matsubara and Naoki Haratake and Takaki Akamine and Nobutaka Mukae and Fumihiko Hirai and Tetsuzo Tagawa and Yoshinao Oda and Toru Iwaki and Koji Iihara and Hiroshi Honda and Yoshihiko Maehara",

year = "2018",

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doi = "10.21873/anticanres.12653",

language = "English",

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AU - Takamori, Shinkichi

AU - Toyokawa, Gouji

AU - Shimokawa, Mototsugu

AU - Kinoshita, Fumihiko

AU - Kozuma, Yuka

AU - Matsubara, Taichi

AU - Haratake, Naoki

AU - Akamine, Takaki

AU - Mukae, Nobutaka

AU - Hirai, Fumihiko

AU - Tagawa, Tetsuzo

AU - Oda, Yoshinao

AU - Iwaki, Toru

AU - Iihara, Koji

AU - Honda, Hiroshi

AU - Maehara, Yoshihiko

PY - 2018/6

Y1 - 2018/6

N2 - Aim: To investigate the radiological features on computed tomography (CT) of brain metastasis (BM) from epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). Patients and Methods: Thirty-four patients with NSCLC with BMs who underwent surgical resection of the BMs at the Department of Neurosurgery, Kyushu University from 2005 to 2016 were enrolled in the study. The EGFR statuses of the 34 BMs were investigated. Radiological features, including the number, size, and location of the tumor, were delineated by CT. Results: Patients with EGFR-mutated BMs had significantly higher frequencies of multiple metastases than those with the non-EGFR-mutated type (p=0.042). BMs harboring mutations in EGFR were more frequently observed in the central area of the brain compared to those without mutations in EGFR (p=0.037). Conclusion: Careful follow-up of patients with EGFR-mutated NSCLC may be necessary given the high frequencies of multiple BMs and their location in the central area of the brain.

AB - Aim: To investigate the radiological features on computed tomography (CT) of brain metastasis (BM) from epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). Patients and Methods: Thirty-four patients with NSCLC with BMs who underwent surgical resection of the BMs at the Department of Neurosurgery, Kyushu University from 2005 to 2016 were enrolled in the study. The EGFR statuses of the 34 BMs were investigated. Radiological features, including the number, size, and location of the tumor, were delineated by CT. Results: Patients with EGFR-mutated BMs had significantly higher frequencies of multiple metastases than those with the non-EGFR-mutated type (p=0.042). BMs harboring mutations in EGFR were more frequently observed in the central area of the brain compared to those without mutations in EGFR (p=0.037). Conclusion: Careful follow-up of patients with EGFR-mutated NSCLC may be necessary given the high frequencies of multiple BMs and their location in the central area of the brain.

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Radiological features of brain metastases from non-small cell lung cancer harboring EGFR mutation

Abstract

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