Quantitative Perfusion Imaging with Pulsed Arterial Spin Labeling: A phantom study

Tomoyuki Noguchi, Takashi Yoshiura, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kouji Kobayashi, Futoshi Mihara, Hiroshi Honda

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Purpose: Pulsed arterial spin labeling (PASL) is a magnetic resonance (MR) method for measuring cerebral blood flow. Although several validation studies for PASL in animals and humans have been reported, no reports have detailed the fundamental study of PASL using a flow phantom. We compared the true and theoretical flow rates in a flow phantom to confirm the analytical validity of quantitative perfusion imaging with Q2TIPS sequence. Methods: We built a flow phantom consisting of a 40-mm diameter plastic syringe filled with plastic beads and small plastic tubes 4 mm in diameter. Gd-DTPA-doped 8L water solution (0.1 mM) was circulated between the syringe and a tank through a plastic tube by a constant flow pump while the flow rate was adjusted between 0 and 2.61 cm/s. Q2TIPS sequence parameters were TI1 = 50 ms and TI2 = 1400 ms. Five imaging slices of 50 subtraction images were acquired sequentially in a distal-to-proximal direction using a single-shot echo planar imaging (EPI) technique. The theoretical flow rate calculated based upon the previously reported kinetic model for Q2TIPS was compared with the true flow rate. Results: A good linear relationship was observed between the theoretical, F', and true flow rates, F, in a flow rate range of 1.43 to 1.95 cm/s (F = 1.024-F- 1.915, R2 = 0.902). The ratio of theoretical to true flow rate was 92 (+/-) 4%. Conclusion: Flow rate was quantified with reasonable accuracy when the entire amount of labeled bolus within the phantom could be recovered. Our experiment confirmed the analytical validity of Q2TIPS and suggested that blood flow measurement may be feasible using the Q2TIPS pulse sequence and kinetic model of the PASL equation.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalMagnetic Resonance in Medical Sciences
Issue number2
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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