Quantitative evaluation of magnetic immunoassay with remanence measurement

K. Enpuku; K. Soejima; T. Nishimoto; H. Kuma; N. Hamasaki; A. Tsukamoto; K. Saitoh; A. Kandori

doi:10.1088/0953-2048/19/5/S19

Quantitative evaluation of magnetic immunoassay with remanence measurement

K. Enpuku, K. Soejima, T. Nishimoto, H. Kuma, N. Hamasaki, A. Tsukamoto, K. Saitoh, A. Kandori

Superconductive Systems Engineering Laboratory

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Magnetic immunoassays utilizing magnetic markers and a high -T_c SQUID have been performed. The marker was designed so as to generate remanence, and its remanence field was measured with the SQUID. The SQUID system was developed so as to measure 12 samples in one measurement sequence. We first conducted a detection of antigen called human IgE using IgE standard solution, and showed the detection of IgE down to 2 attomol. The binding process between IgE and the marker could be semi-quantitatively explained with the Langmuir-type adsorption model. We also measured IgE in human serums, and demonstrated the usefulness of the present method for practical diagnosis.

Original language	English
Pages (from-to)	S257-S260
Journal	Superconductor Science and Technology
Volume	19
Issue number	5
DOIs	https://doi.org/10.1088/0953-2048/19/5/S19
Publication status	Published - May 1 2006

All Science Journal Classification (ASJC) codes

Ceramics and Composites
Condensed Matter Physics
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1088/0953-2048/19/5/S19

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AU - Enpuku, K.

AU - Soejima, K.

AU - Nishimoto, T.

AU - Kuma, H.

AU - Hamasaki, N.

AU - Tsukamoto, A.

AU - Saitoh, K.

AU - Kandori, A.

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AB - Magnetic immunoassays utilizing magnetic markers and a high -Tc SQUID have been performed. The marker was designed so as to generate remanence, and its remanence field was measured with the SQUID. The SQUID system was developed so as to measure 12 samples in one measurement sequence. We first conducted a detection of antigen called human IgE using IgE standard solution, and showed the detection of IgE down to 2 attomol. The binding process between IgE and the marker could be semi-quantitatively explained with the Langmuir-type adsorption model. We also measured IgE in human serums, and demonstrated the usefulness of the present method for practical diagnosis.

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Quantitative evaluation of magnetic immunoassay with remanence measurement

Abstract

All Science Journal Classification (ASJC) codes

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