Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT: comparison with 3-Tesla MRI

Yuzo Yamasaki; Michinobu Nagao; Kenichiro Yamamura; Masato Yonezawa; Yoshio Matsuo; Satoshi Kawanami; Takeshi Kamitani; Ko Higuchi; Ichiro Sakamoto; Yuichi Shiokawa; Hidetake Yabuuchi; Hiroshi Honda

doi:10.1007/s00330-014-3344-1

Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT: comparison with 3-Tesla MRI

Yuzo Yamasaki, Michinobu Nagao, Kenichiro Yamamura, Masato Yonezawa, Yoshio Matsuo, Satoshi Kawanami, Takeshi Kamitani, Ko Higuchi, Ichiro Sakamoto, Yuichi Shiokawa, Hidetake Yabuuchi, Hiroshi Honda

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Objectives: To compare 256-slice cardiac computed tomography (CCT) with cardiac magnetic resonance (CMR) imaging to assess right ventricular (RV) function and pulmonary regurgitant fraction (PRF) in patients with repaired tetralogy of Fallot (TOF).

Methods: Thirty-three consecutive patients with repaired TOF underwent retrospective ECG-gated CCT and 3-Tesla CMR. RV and left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were measured using CCT and CMR. PRF-CCT (%) was defined as (RVSV − LVSV)/RVSV. PRF-CMR (%) was measured by the phase-contrast method. Repeated measurements were performed to determine intra- and interobserver variability.

Results: CCT measurements, including PRF, correlated highly with the CMR reference (r = 0.71–0.96). CCT overestimated RVEDV (mean difference, 17.1 ± 2.9 ml), RVESV (12.9 ± 2.1 ml) and RVSV (4.2 ± 2.0 ml), and underestimated RVEF (−2.6 ± 1.0 %) and PRF (−9.1 ± 2.0 %) compared with CMR. The limits of agreement between CCT and CMR were in a good range for all measurements. The variability in CCT measurements was lower than those in CMR. The estimated effective radiation dose was 7.6 ± 2.6 mSv.

Conclusions: 256-slice CCT can assess RV function and PRF with relatively low dose radiation exposure in patients with repaired TOF, but overestimates RV volume and underestimates PRF.

Key points: • 256-slice CT assessment of RV function is highly reproducible in repaired TOF.

• Pulmonary regurgitation can be evaluated by biventricular systolic volume difference.

• CT overestimates RV volume and underestimates pulmonary regurgitation, compared with MRI.

Original language	English
Pages (from-to)	3289-3299
Number of pages	11
Journal	European Radiology
Volume	24
Issue number	12
DOIs	https://doi.org/10.1007/s00330-014-3344-1
Publication status	Published - Nov 14 2014

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1007/s00330-014-3344-1

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Yamasaki, Y., Nagao, M., Yamamura, K., Yonezawa, M., Matsuo, Y., Kawanami, S., Kamitani, T., Higuchi, K., Sakamoto, I., Shiokawa, Y., Yabuuchi, H., & Honda, H. (2014). Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT: comparison with 3-Tesla MRI. European Radiology, 24(12), 3289-3299. https://doi.org/10.1007/s00330-014-3344-1

Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT: comparison with 3-Tesla MRI. / Yamasaki, Yuzo; Nagao, Michinobu; Yamamura, Kenichiro et al.
In: European Radiology, Vol. 24, No. 12, 14.11.2014, p. 3289-3299.

Research output: Contribution to journal › Article › peer-review

Yamasaki, Y, Nagao, M, Yamamura, K, Yonezawa, M, Matsuo, Y, Kawanami, S, Kamitani, T, Higuchi, K, Sakamoto, I, Shiokawa, Y, Yabuuchi, H & Honda, H 2014, 'Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT: comparison with 3-Tesla MRI', European Radiology, vol. 24, no. 12, pp. 3289-3299. https://doi.org/10.1007/s00330-014-3344-1

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title = "Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT: comparison with 3-Tesla MRI",

abstract = "Objectives: To compare 256-slice cardiac computed tomography (CCT) with cardiac magnetic resonance (CMR) imaging to assess right ventricular (RV) function and pulmonary regurgitant fraction (PRF) in patients with repaired tetralogy of Fallot (TOF).Methods: Thirty-three consecutive patients with repaired TOF underwent retrospective ECG-gated CCT and 3-Tesla CMR. RV and left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were measured using CCT and CMR. PRF-CCT (%) was defined as (RVSV − LVSV)/RVSV. PRF-CMR (%) was measured by the phase-contrast method. Repeated measurements were performed to determine intra- and interobserver variability.Results: CCT measurements, including PRF, correlated highly with the CMR reference (r = 0.71–0.96). CCT overestimated RVEDV (mean difference, 17.1 ± 2.9 ml), RVESV (12.9 ± 2.1 ml) and RVSV (4.2 ± 2.0 ml), and underestimated RVEF (−2.6 ± 1.0 %) and PRF (−9.1 ± 2.0 %) compared with CMR. The limits of agreement between CCT and CMR were in a good range for all measurements. The variability in CCT measurements was lower than those in CMR. The estimated effective radiation dose was 7.6 ± 2.6 mSv.Conclusions: 256-slice CCT can assess RV function and PRF with relatively low dose radiation exposure in patients with repaired TOF, but overestimates RV volume and underestimates PRF.Key points: • 256-slice CT assessment of RV function is highly reproducible in repaired TOF.• Pulmonary regurgitation can be evaluated by biventricular systolic volume difference.• CT overestimates RV volume and underestimates pulmonary regurgitation, compared with MRI.",

author = "Yuzo Yamasaki and Michinobu Nagao and Kenichiro Yamamura and Masato Yonezawa and Yoshio Matsuo and Satoshi Kawanami and Takeshi Kamitani and Ko Higuchi and Ichiro Sakamoto and Yuichi Shiokawa and Hidetake Yabuuchi and Hiroshi Honda",

note = "Funding Information: Higuchi K.: Philips Electronics Japan, Employee. This study has received funding by the Japan Society for the Promotion of Science (JSPS) KAKENHI (25461831). No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, diagnostic study, performed at one institution. Publisher Copyright: {\textcopyright} 2014, European Society of Radiology.",

year = "2014",

month = nov,

day = "14",

doi = "10.1007/s00330-014-3344-1",

language = "English",

volume = "24",

pages = "3289--3299",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer Verlag",

number = "12",

}

TY - JOUR

T1 - Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT

T2 - comparison with 3-Tesla MRI

AU - Yamasaki, Yuzo

AU - Nagao, Michinobu

AU - Yamamura, Kenichiro

AU - Yonezawa, Masato

AU - Matsuo, Yoshio

AU - Kawanami, Satoshi

AU - Kamitani, Takeshi

AU - Higuchi, Ko

AU - Sakamoto, Ichiro

AU - Shiokawa, Yuichi

AU - Yabuuchi, Hidetake

AU - Honda, Hiroshi

N1 - Funding Information: Higuchi K.: Philips Electronics Japan, Employee. This study has received funding by the Japan Society for the Promotion of Science (JSPS) KAKENHI (25461831). No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, diagnostic study, performed at one institution. Publisher Copyright: © 2014, European Society of Radiology.

PY - 2014/11/14

Y1 - 2014/11/14

N2 - Objectives: To compare 256-slice cardiac computed tomography (CCT) with cardiac magnetic resonance (CMR) imaging to assess right ventricular (RV) function and pulmonary regurgitant fraction (PRF) in patients with repaired tetralogy of Fallot (TOF).Methods: Thirty-three consecutive patients with repaired TOF underwent retrospective ECG-gated CCT and 3-Tesla CMR. RV and left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were measured using CCT and CMR. PRF-CCT (%) was defined as (RVSV − LVSV)/RVSV. PRF-CMR (%) was measured by the phase-contrast method. Repeated measurements were performed to determine intra- and interobserver variability.Results: CCT measurements, including PRF, correlated highly with the CMR reference (r = 0.71–0.96). CCT overestimated RVEDV (mean difference, 17.1 ± 2.9 ml), RVESV (12.9 ± 2.1 ml) and RVSV (4.2 ± 2.0 ml), and underestimated RVEF (−2.6 ± 1.0 %) and PRF (−9.1 ± 2.0 %) compared with CMR. The limits of agreement between CCT and CMR were in a good range for all measurements. The variability in CCT measurements was lower than those in CMR. The estimated effective radiation dose was 7.6 ± 2.6 mSv.Conclusions: 256-slice CCT can assess RV function and PRF with relatively low dose radiation exposure in patients with repaired TOF, but overestimates RV volume and underestimates PRF.Key points: • 256-slice CT assessment of RV function is highly reproducible in repaired TOF.• Pulmonary regurgitation can be evaluated by biventricular systolic volume difference.• CT overestimates RV volume and underestimates pulmonary regurgitation, compared with MRI.

AB - Objectives: To compare 256-slice cardiac computed tomography (CCT) with cardiac magnetic resonance (CMR) imaging to assess right ventricular (RV) function and pulmonary regurgitant fraction (PRF) in patients with repaired tetralogy of Fallot (TOF).Methods: Thirty-three consecutive patients with repaired TOF underwent retrospective ECG-gated CCT and 3-Tesla CMR. RV and left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were measured using CCT and CMR. PRF-CCT (%) was defined as (RVSV − LVSV)/RVSV. PRF-CMR (%) was measured by the phase-contrast method. Repeated measurements were performed to determine intra- and interobserver variability.Results: CCT measurements, including PRF, correlated highly with the CMR reference (r = 0.71–0.96). CCT overestimated RVEDV (mean difference, 17.1 ± 2.9 ml), RVESV (12.9 ± 2.1 ml) and RVSV (4.2 ± 2.0 ml), and underestimated RVEF (−2.6 ± 1.0 %) and PRF (−9.1 ± 2.0 %) compared with CMR. The limits of agreement between CCT and CMR were in a good range for all measurements. The variability in CCT measurements was lower than those in CMR. The estimated effective radiation dose was 7.6 ± 2.6 mSv.Conclusions: 256-slice CCT can assess RV function and PRF with relatively low dose radiation exposure in patients with repaired TOF, but overestimates RV volume and underestimates PRF.Key points: • 256-slice CT assessment of RV function is highly reproducible in repaired TOF.• Pulmonary regurgitation can be evaluated by biventricular systolic volume difference.• CT overestimates RV volume and underestimates pulmonary regurgitation, compared with MRI.

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Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT: comparison with 3-Tesla MRI

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