Pursaethosides A-E, triterpene saponins from Entada pursaetha

Azefack Léon Tapondjou, Tomofumi Miyamoto, Jean François Mirjolet, Nicolas Guilbaud, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the η-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.

Original languageEnglish
Pages (from-to)1185-1190
Number of pages6
JournalJournal of Natural Products
Issue number8
Publication statusPublished - Aug 2005

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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