PTPN3 Could Be a Therapeutic Target of Pancreatic Cancer

Hideya Onishi; Naoya Iwamoto; Keita Sakanashi; Satoko Koga; Yasuhiro Oyama; Kosuke Yanai; Katsuya Nakamura; Shuntaro Nagai; Akiko Fujimura; Kazunori Nakayama; Keigo Ozono; Akio Yamasaki

doi:10.21873/anticanres.15768

PTPN3 Could Be a Therapeutic Target of Pancreatic Cancer

Hideya Onishi, Naoya Iwamoto, Keita Sakanashi, Satoko Koga, Yasuhiro Oyama, Kosuke Yanai, Katsuya Nakamura, Shuntaro Nagai, Akiko Fujimura, Kazunori Nakayama, Keigo Ozono, Akio Yamasaki

Research output: Contribution to journal › Article › peer-review

Abstract

Background/Aim: Recently, protein tyrosine phosphatase non-receptor type 3 (PTPN3) has gained attention. However, the role of PTPN3 in cancer has not been fully elucidated. In the present study, we analyzed the role of PTPN3 in pancreatic cancer and investigated whether PTPN3 could be a new therapeutic target for pancreatic cancer. Materials and Methods: Two pancreatic ductal adenocarcinoma (PDAC) cell lines were used as target cells. Cell proliferation was investigated using cell counting and a xenograft mouse model. Migration and invasion were analyzed using Transwell inserts. Activation-related signaling molecules were examined by western blotting. Results: PTPN3 contributes to the proliferation, migration, and invasion of PDAC cells in vitro. PTPN3 promotes tumor growth in a mouse xenograft model, an action mediated partially through the MAPK pathway. Conclusion: PTPN3 could be a new therapeutic target for pancreatic cancer.

Original language	English
Pages (from-to)	2869-2874
Number of pages	6
Journal	Anticancer research
Volume	42
Issue number	6
DOIs	https://doi.org/10.21873/anticanres.15768
Publication status	Published - Jun 2022

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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@article{e08ec9ec9ac54e3baa886f2ed9f7a65a,

title = "PTPN3 Could Be a Therapeutic Target of Pancreatic Cancer",

abstract = "Background/Aim: Recently, protein tyrosine phosphatase non-receptor type 3 (PTPN3) has gained attention. However, the role of PTPN3 in cancer has not been fully elucidated. In the present study, we analyzed the role of PTPN3 in pancreatic cancer and investigated whether PTPN3 could be a new therapeutic target for pancreatic cancer. Materials and Methods: Two pancreatic ductal adenocarcinoma (PDAC) cell lines were used as target cells. Cell proliferation was investigated using cell counting and a xenograft mouse model. Migration and invasion were analyzed using Transwell inserts. Activation-related signaling molecules were examined by western blotting. Results: PTPN3 contributes to the proliferation, migration, and invasion of PDAC cells in vitro. PTPN3 promotes tumor growth in a mouse xenograft model, an action mediated partially through the MAPK pathway. Conclusion: PTPN3 could be a new therapeutic target for pancreatic cancer.",

author = "Hideya Onishi and Naoya Iwamoto and Keita Sakanashi and Satoko Koga and Yasuhiro Oyama and Kosuke Yanai and Katsuya Nakamura and Shuntaro Nagai and Akiko Fujimura and Kazunori Nakayama and Keigo Ozono and Akio Yamasaki",

note = "Funding Information: The Authors thank Ms. Emi Onishi for her technical assistance. This study was supported by JSPS KAKENHI Grant Numbers JP 20K09180, JP 21K08672, and JP 21K09583. The Authors would like to thank Editage (www.editage.com) for English language editing. Publisher Copyright: {\textcopyright} 2022 International Institute of Anticancer Research. All rights reserved.",

year = "2022",

month = jun,

doi = "10.21873/anticanres.15768",

language = "English",

volume = "42",

pages = "2869--2874",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "6",

}

TY - JOUR

T1 - PTPN3 Could Be a Therapeutic Target of Pancreatic Cancer

AU - Onishi, Hideya

AU - Iwamoto, Naoya

AU - Sakanashi, Keita

AU - Koga, Satoko

AU - Oyama, Yasuhiro

AU - Yanai, Kosuke

AU - Nakamura, Katsuya

AU - Nagai, Shuntaro

AU - Fujimura, Akiko

AU - Nakayama, Kazunori

AU - Ozono, Keigo

AU - Yamasaki, Akio

N1 - Funding Information: The Authors thank Ms. Emi Onishi for her technical assistance. This study was supported by JSPS KAKENHI Grant Numbers JP 20K09180, JP 21K08672, and JP 21K09583. The Authors would like to thank Editage (www.editage.com) for English language editing. Publisher Copyright: © 2022 International Institute of Anticancer Research. All rights reserved.

PY - 2022/6

Y1 - 2022/6

N2 - Background/Aim: Recently, protein tyrosine phosphatase non-receptor type 3 (PTPN3) has gained attention. However, the role of PTPN3 in cancer has not been fully elucidated. In the present study, we analyzed the role of PTPN3 in pancreatic cancer and investigated whether PTPN3 could be a new therapeutic target for pancreatic cancer. Materials and Methods: Two pancreatic ductal adenocarcinoma (PDAC) cell lines were used as target cells. Cell proliferation was investigated using cell counting and a xenograft mouse model. Migration and invasion were analyzed using Transwell inserts. Activation-related signaling molecules were examined by western blotting. Results: PTPN3 contributes to the proliferation, migration, and invasion of PDAC cells in vitro. PTPN3 promotes tumor growth in a mouse xenograft model, an action mediated partially through the MAPK pathway. Conclusion: PTPN3 could be a new therapeutic target for pancreatic cancer.

AB - Background/Aim: Recently, protein tyrosine phosphatase non-receptor type 3 (PTPN3) has gained attention. However, the role of PTPN3 in cancer has not been fully elucidated. In the present study, we analyzed the role of PTPN3 in pancreatic cancer and investigated whether PTPN3 could be a new therapeutic target for pancreatic cancer. Materials and Methods: Two pancreatic ductal adenocarcinoma (PDAC) cell lines were used as target cells. Cell proliferation was investigated using cell counting and a xenograft mouse model. Migration and invasion were analyzed using Transwell inserts. Activation-related signaling molecules were examined by western blotting. Results: PTPN3 contributes to the proliferation, migration, and invasion of PDAC cells in vitro. PTPN3 promotes tumor growth in a mouse xenograft model, an action mediated partially through the MAPK pathway. Conclusion: PTPN3 could be a new therapeutic target for pancreatic cancer.

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JO - Anticancer research

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PTPN3 Could Be a Therapeutic Target of Pancreatic Cancer

Abstract

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