Psychological stress impairs hepatic blood flow via central CRF receptors in mice

Yoichi Chida, Nobuyuki Sudo, Chiharu Kubo

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Some previous works have further expanded the 'Brain-Gut axis', that is a bi-directional interaction between the gut and brain function, into a relationship of the brain with the liver. However, all the details of such brain-liver relationship were not fully understood because appropriate animal models had not been established yet. Here we developed a novel animal model, in which hepatic blood flow of conscious mice could be measured in real-time. In addition, using this model, we also demonstrated that exposure to psychological stress considerably reduced hepatic blood flow via central CRF receptors. Thus, this new model is considered to be a useful and promising tool for elucidating the precise effects of emotional factors on liver function.

Original languageEnglish
Pages (from-to)1707-1712
Number of pages6
JournalLife Sciences
Issue number15
Publication statusPublished - Feb 25 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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