Psoriasis and the TNF/IL23/IL17 axis

Kazuhisa Furue, Takamichi Ito, Gaku Tsuji, Takafumi Kadono, Masutaka Furue

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)


The excellent response of psoriasis to anti-TNF-α(TNF)/IL23/IL17A biologics implies a crucial role for the TNF/IL23/IL17 axis in developing psoriasis. In addition to the TNF/IL23/IL17 axis provided by immune cells, current evidence points to an important contribution of TNF, IL23 and IL17C produced from non-hematopoietic keratinocytes. Therefore, crosstalk between immune cells and keratinocytes forms a multilayered feed-forward loop to accelerate the TNF/IL23/IL17A axis. Many biologics have already been licensed or are under clinical trials. Given that the IL-17 signature is more upregulated in the skin than in synovium in psoriatic arthritis, anti-IL-23/IL-17 agents seem to be superior to anti-TNF-α remedies in the treatment of skin lesions. In this review, we summarize recent topics in psoriasis and the TNF/IL23/IL17 axis.

Original languageEnglish
Pages (from-to)418-424
Number of pages7
JournalGiornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
Issue number4
Publication statusPublished - Aug 1 2019

All Science Journal Classification (ASJC) codes

  • Dermatology


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