Proteomic studies of lipopolysaccharide-induced polypeptides in the silkworm, Bombyx mori

Yongqiang Wang, Pingbo Zhang, Hiroshi Fujii, Yutaka Banno, Kohji Yamamoto, Yoichi Aso

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Silkworm larvae at the 5th instar were injected with lipopolysaccharide from Escherichia coli and inducible polypeptides were examined within a pI range of 3-10 and a size range of 14-97 kDa by proteomics, including peptide mass fingerprinting. No polypeptides were induced in the midgut. FB1 and H1-4 polypeptides were significantly induced in fat body and hemolymph, respectively. FB1 and H1 were estimated to be antitrypsin and serpin-2 proteinase inhibitors respectively. H2 and H3 were novel polypeptides. H4 was estimated to be attacin antibacterial polypeptide with high coverage of sequence. The amounts of all the induced polypeptides decreased at 48 h after the injection.

Original languageEnglish
Pages (from-to)1821-1823
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number8
Publication statusPublished - Aug 2004

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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