Protein S and protein C gene mutations in Japanese deep vein thrombosis patients

Sachiko Kinoshita, Hiroko Iida, Sumiko Inoue, Kumiko Watanabe, Masako Kurihara, Yui Wada, Hiroko Tsuda, Dongchon Kang, Naotaka Hamasaki

Research output: Contribution to journalArticlepeer-review

97 Citations (Scopus)


Objectives: Coagulation factor V Leiden has not been detected in Japanese patients suffering from thrombosis. Hitherto, the constitutional background of Japanese thrombotic patients has never been systematically examined. We have performed a systematic investigation to determine pathogenesis for deep vein thrombosis in a Japanese population. Design and methods: Routine coagulation and fibrinolysis tests were performed to determine the activities of protein S, protein C, antithrombin, plasminogen and fibrinogen. Gene analysis was performed in thrombotic patients having low activities of these factors. Results: Our study indicates that the frequency (19/85 = 0.22) of mutations of protein S gene in the Japanese patients was 5-10 times higher than that of mutations of protein S gene in Caucasian patients, and the frequency (8/85 = 0.09) of mutations of protein C gene was almost three times higher than that of Caucasian patients. The frequency of antithrombin gene mutation was similar in both populations. Conclusion: Our study reinforces that the genetic anomaly in the protein S/protein C anticoagulation system is an important risk factor for thrombophilia in the Japanese population.

Original languageEnglish
Pages (from-to)908-915
Number of pages8
JournalClinical Biochemistry
Issue number10
Publication statusPublished - Oct 2005

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry


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