Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome

Sachie Toki; Kenji Hiromatsu; Yoshiyasu Aoki; Masahiko Makino; Yasunobu Yoshikai

doi:10.1006/cyto.1997.0231

Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome

Sachie Toki, Kenji Hiromatsu, Yoshiyasu Aoki, Masahiko Makino, Yasunobu Yoshikai

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Mice with retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS) were hypersensitive to lipopolysaccharide (LPS)-induced lethal shock accompanied by marked elevations of systemic interleukin 1β (IL-β) and interferon γ (IFN-γ) after LPS challenge. Pretreatment with 10 μg of recombinant human granulocyte colony-stimulating factor (rhG-CSF) protected MAIDS mice from hypersensitivity to LPS-induced lethal shock and this protection was concomitant with suppression of IFN-γ production.

Original language	English
Pages (from-to)	781-786
Number of pages	6
Journal	Cytokine
Volume	9
Issue number	10
DOIs	https://doi.org/10.1006/cyto.1997.0231
Publication status	Published - Oct 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Biochemistry
Hematology
Molecular Biology

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10.1006/cyto.1997.0231

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title = "Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome",

abstract = "Mice with retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS) were hypersensitive to lipopolysaccharide (LPS)-induced lethal shock accompanied by marked elevations of systemic interleukin 1β (IL-β) and interferon γ (IFN-γ) after LPS challenge. Pretreatment with 10 μg of recombinant human granulocyte colony-stimulating factor (rhG-CSF) protected MAIDS mice from hypersensitivity to LPS-induced lethal shock and this protection was concomitant with suppression of IFN-γ production.",

author = "Sachie Toki and Kenji Hiromatsu and Yoshiyasu Aoki and Masahiko Makino and Yasunobu Yoshikai",

note = "Funding Information: We thank Kirin Brewery Co[ Ltd for providing rhG!CSF[ This work was supported by grants to Y[ Y[ from the Ministry of Education\ Science\ Sports and Culture\ and the Ministry of Health and Welfare[",

year = "1997",

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T1 - Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome

AU - Toki, Sachie

AU - Hiromatsu, Kenji

AU - Aoki, Yoshiyasu

AU - Makino, Masahiko

AU - Yoshikai, Yasunobu

N1 - Funding Information: We thank Kirin Brewery Co[ Ltd for providing rhG!CSF[ This work was supported by grants to Y[ Y[ from the Ministry of Education\ Science\ Sports and Culture\ and the Ministry of Health and Welfare[

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Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome

Abstract

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