@inbook{debc77cb1df54e4382c3a64a030e5881,
title = "Prospective potency of TGF-β1 on maintenance and regeneration of periodontal tissue",
abstract = "Periodontal ligament (PDL) tissue, central in the periodontium, plays crucial roles in sustaining tooth in the bone socket. Irreparable damages of this tissue provoke tooth loss, causing a decreased quality of life. The question arises as to how PDL tissue is maintained or how the lost PDL tissue can be regenerated. Stem cells included in PDL tissue (PDLSCs) are widely accepted to have the potential to maintain or regenerate the periodontium, but PDLSCs are very few in number. In recent studies, undifferentiated clonal human PDL cell lines were developed to elucidate the applicable potentials of PDLSCs for the periodontal regenerative medicine based on cell-based tissue engineering. In addition, it has been suggested that transforming growth factor-beta 1 is an eligible factor for the maintenance and regeneration of PDL tissue.",
author = "Hidefumi Maeda and Naohisa Wada and Atsushi Tomokiyo and Satoshi Monnouchi and Akifumi Akamine",
note = "Funding Information: The authors thank Drs. Fujii, Kono, Koori, and Yamamoto for their great support in preparation of this review. Our own work described here was financially supported by grants-in-aid (projects 22390359, 23659890, 23689077, 24390426, 24659848, 24792028, 25293388, 25670811) for scientific research from the Japanese Ministry of Education, Culture, Sports, Science, and Technology.",
year = "2013",
doi = "10.1016/B978-0-12-407696-9.00006-3",
language = "English",
series = "International Review of Cell and Molecular Biology",
publisher = "Elsevier Inc.",
pages = "283--367",
booktitle = "International Review of Cell and Molecular Biology",
address = "United States",
}
