Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection

Motohiko Okano, Keisei Kawa, Hiroshi Kimura, Akihiro Yachie, Hiroshi Wakiguchi, Akihiko Maeda, Shosuke Imai, Shouichi Ohga, Hirokazu Kanegane, Shigeru Tsuchiya, Tomohiro Morio, Masaaki Mori, Shumpei Yokota, Shinsaku Imashuku

Research output: Contribution to journalReview articlepeer-review

222 Citations (Scopus)


Since the initial report of unusual manifestations possibly associated with chronic active Epstein-Barr virus (EBV) infection (CAEBV), nearly three decades have passed. During this period, reported cases with this entity have dramatically increased in the world. Additionally, recent development of diagnostic procedures, including molecular biological and immunological techniques, have provided us with the ability to define certain diseases, especially malignant disorders. Guidelines, derived mainly from the current literature and recent experiences with CAEBV in Japan, for diagnosing CAEBV are proposed to clarify this enigmatic disease.

Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalAmerican Journal of Hematology
Issue number1
Publication statusPublished - Sept 2005

All Science Journal Classification (ASJC) codes

  • Hematology


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