Properties and mechanisms of fast-setting calcium phosphate cements

Kunio Ishikawa, Shozo Takagi, Laurence C. Chow, Yoshiko Ishikawa

Research output: Contribution to journalArticlepeer-review

151 Citations (Scopus)


The setting time of a calcium phosphate cement consisting of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) was reduced from 30 to 5 min by use of a cement liquid that contained a phosphate concentration of 0.25 mol/l or higher. The diametral tensile strength and conversion of the cement ingredients to hydroxyapatite (OHAp) during the first 3 h were also significantly increased by the phosphate. However, the phosphate produced no significant effects on the properties of the 24-h cement samples. Results from additional experiments in a slurry system verified that the high phosphate concentration in the solution accelerated the formation of OHAp in the TTCP + DCPA system, and this reaction could explain the fast-setting properties of the cements.

Original languageEnglish
Pages (from-to)528-533
Number of pages6
JournalJournal of Materials Science: Materials in Medicine
Issue number9
Publication statusPublished - Sept 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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