Promotion of glycerol utilization using ethanol and 1-propanol in Schizosaccharomyces pombe

Tomohiko Matsuzawa, Futoshi Hara, Hideki Tohda, Hiroshi Uemura, Kaoru Takegawa

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The fission yeast Schizosaccharomyces pombe does not grow in media containing glycerol as a sole carbon source but uses glycerol in the presence of ethanol. Ethanol, but not glycerol, triggered upregulation of gld1 + and fbp1 + during glucose starvation even though gld1 + and fbp1 + are essential for growth on glycerol. This upregulation occurred at a very low concentration of ethanol. The transcriptional regulation of gld1 + was tested in the presence of various alcohols, and both ethanol and 1-propanol were found to induce gld1 + and to support growth in glycerol-containing media. We suggest that S. pombe has a novel ethanol and/or 1-propanol recognition mechanism that upregulates glycerol utilization during glucose starvation.

Original languageEnglish
Pages (from-to)441-449
Number of pages9
JournalApplied Microbiology and Biotechnology
Issue number2
Publication statusPublished - Jul 2012

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology


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