Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma

Y. Kakeji, Y. Maehara, Y. Adachi, H. Baba, M. Mori, M. Furusawa, K. Sugimachi

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Proliferative activities in 181 primary Borrmann type 4 gastric carcinomas were investigated using percentage labelling of proliferating cell nuclear antigen (PCNA) and an argyrophilic nucleolar organiser region (AgNOR) count. Tumours with a high proliferative activity often metastasised to lymph nodes (P < 0.01), and these patients had a lower survival rate (P < 0.05). A significant correlation was recognised between the PCNA labelling percentage and AgNOR count (r = 0.452, P < 0.001). Cox's regression analysis showed that PCNA labelling percentage is an independent prognostic factor. These results indicate that estimating proliferative activity may be useful in predicting lymph node metastasis and patients’ prognosis in cases of Borrmann type 4 gastric carcinoma.

Original languageEnglish
Pages (from-to)749-753
Number of pages5
JournalBritish journal of cancer
Issue number4
Publication statusPublished - Apr 1994

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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