Programmable protein-protein conjugation via DNA-based self-assembly

Josui Shimada; Tatsuo Maruyama; Momoko Kitaoka; Hisao Yoshinaga; Koji Nakano; Noriho Kamiya; Masahiro Goto

doi:10.1039/c2cc30618b

Programmable protein-protein conjugation via DNA-based self-assembly

Josui Shimada, Tatsuo Maruyama, Momoko Kitaoka, Hisao Yoshinaga, Koji Nakano, Noriho Kamiya, Masahiro Goto

Applied Chemistry

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Protein molecules were precisely arrayed on a designable DNA scaffold close to each other using a DNA aptamer. By adding a chemical cross-linker, the neighboring protein molecules were effectively and covalently cross-linked to each other without losing their activities.

Original language	English
Pages (from-to)	6226-6228
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	50
DOIs	https://doi.org/10.1039/c2cc30618b
Publication status	Published - May 28 2012

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc30618b

Cite this

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abstract = "Protein molecules were precisely arrayed on a designable DNA scaffold close to each other using a DNA aptamer. By adding a chemical cross-linker, the neighboring protein molecules were effectively and covalently cross-linked to each other without losing their activities.",

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AU - Shimada, Josui

AU - Maruyama, Tatsuo

AU - Kitaoka, Momoko

AU - Yoshinaga, Hisao

AU - Nakano, Koji

AU - Kamiya, Noriho

AU - Goto, Masahiro

PY - 2012/5/28

Y1 - 2012/5/28

N2 - Protein molecules were precisely arrayed on a designable DNA scaffold close to each other using a DNA aptamer. By adding a chemical cross-linker, the neighboring protein molecules were effectively and covalently cross-linked to each other without losing their activities.

AB - Protein molecules were precisely arrayed on a designable DNA scaffold close to each other using a DNA aptamer. By adding a chemical cross-linker, the neighboring protein molecules were effectively and covalently cross-linked to each other without losing their activities.

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JF - Chemical Communications

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Programmable protein-protein conjugation via DNA-based self-assembly

Abstract

All Science Journal Classification (ASJC) codes

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