Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma

T. Nakashima, R. Yasumatsu, M. Masuda, G. L. Clayman, S. Komune

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Objective: To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma. Design: Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival. Results: The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma. Conclusion: Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma.

Original languageEnglish
Pages (from-to)1134-1137
Number of pages4
JournalJournal of Laryngology and Otology
Issue number11
Publication statusPublished - Nov 2012

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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