Prognostic Significance of Preoperative Urine Cytology in Low-grade Non-muscle-invasive Bladder Cancer

Keijiro Kiyoshima, Masakazu Akitake, Masaki Shiota, Ario Takeuchi, Ryosuke Takahashi, Junichi Inokuchi, Katsunori Tatsugami, Akira Yokomizo, Masatoshi Eto

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


AIM: To examine the clinical significance of preoperative urine cytology in patients with low-grade bladder cancer.

PATIENTS AND METHODS: We retrospectively investigated the records of 155 patients diagnosed with primary low-grade (Ta) urothelial carcinoma of the bladder between January 2000 and September 2014.

RESULTS: Patients with class III or greater cytology had significantly higher-grade (G2) (p=0.01), larger tumors (≥15 mm, p=0.0009) and significantly shorter recurrence-free survival compared to patients with class II or lower cytology (p<0.0001). However, Cox proportional hazards analysis for recurrence-free survival only identified tumor size (≥15 mm) (hazard ratio=5.97, 95% confidence interval=2.39-17.29; p<0.0001) as a predictor of poor prognosis, although patients with class III or higher preoperative cytology showed a tendency towards frequent intravesical recurrence (hazard ratio=1.98, 95% confidence interval=0.96-4.2; p=0.063).

CONCLUSION: Preoperative urine cytology, in addition to tumor size, might be a useful predictor of intravesical recurrence of bladder cancer.

Original languageEnglish
Pages (from-to)799-802
Number of pages4
JournalAnticancer research
Issue number2
Publication statusPublished - Feb 1 2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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