Prognostic significance of High Mobility Group Box 1 (HMGB1) expression in patients with colorectal cancer

Masami Ueda; Yusuke Takahashi; Yoshiaki Shinden; Shotaro Sakimura; Hidenari Hirata; Ryutaro Uchi; Yuki Takano; Junji Kurashige; Tomohiro Iguchi; Hidetoshi Eguchi; Keishi Sugimachi; Hirofumi Yamamoto; Yuichiro Doki; Masaki Mori; Koshi Mimori

Prognostic significance of High Mobility Group Box 1 (HMGB1) expression in patients with colorectal cancer

Masami Ueda, Yusuke Takahashi, Yoshiaki Shinden, Shotaro Sakimura, Hidenari Hirata, Ryutaro Uchi, Yuki Takano, Junji Kurashige, Tomohiro Iguchi, Hidetoshi Eguchi, Keishi Sugimachi, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Koshi Mimori

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Background: High mobility group 1 (HMGB1) is a highly conserved non-histone nucleosomal protein in mammals. We investigated the clinical significance of HMGB1 expression in colorectal cancer (CRC). Patients and Methods: The expression of HMGB1 mRNA in 140 tumor and normal tissues from CRC patients was examined by quantitative real-time polymerase chain reaction (PCR). We immunohistochemically investigated HMGB1 expression in tumor and metastatic lymph nodes in CRC. Results: HMGB1 expression was significantly higher in tumor than in normal tissues. High HMGB1 expression was associated with larger tumor volumes, higher rates of lymphatic invasion, more frequent lymph node metastases and poorer prognoses for overall survival. Multivariate analyses showed that HMGB1 expression was an independent prognostic indicator of overall survival. Immunocytochemical analysis revealed that HMGB1 was overexpressed in both CRC tissues and regional lymph node metastases. Conclusion: Investigating HMGB1 expression may be a predictor of postoperative lymph node metastasis and prognosis in CRC.

Original language	English
Pages (from-to)	5357-5362
Number of pages	6
Journal	Anticancer research
Volume	34
Issue number	10
Publication status	Published - Oct 1 2014

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Prognostic significance of High Mobility Group Box 1 (HMGB1) expression in patients with colorectal cancer",

abstract = "Background: High mobility group 1 (HMGB1) is a highly conserved non-histone nucleosomal protein in mammals. We investigated the clinical significance of HMGB1 expression in colorectal cancer (CRC). Patients and Methods: The expression of HMGB1 mRNA in 140 tumor and normal tissues from CRC patients was examined by quantitative real-time polymerase chain reaction (PCR). We immunohistochemically investigated HMGB1 expression in tumor and metastatic lymph nodes in CRC. Results: HMGB1 expression was significantly higher in tumor than in normal tissues. High HMGB1 expression was associated with larger tumor volumes, higher rates of lymphatic invasion, more frequent lymph node metastases and poorer prognoses for overall survival. Multivariate analyses showed that HMGB1 expression was an independent prognostic indicator of overall survival. Immunocytochemical analysis revealed that HMGB1 was overexpressed in both CRC tissues and regional lymph node metastases. Conclusion: Investigating HMGB1 expression may be a predictor of postoperative lymph node metastasis and prognosis in CRC.",

author = "Masami Ueda and Yusuke Takahashi and Yoshiaki Shinden and Shotaro Sakimura and Hidenari Hirata and Ryutaro Uchi and Yuki Takano and Junji Kurashige and Tomohiro Iguchi and Hidetoshi Eguchi and Keishi Sugimachi and Hirofumi Yamamoto and Yuichiro Doki and Masaki Mori and Koshi Mimori",

year = "2014",

month = oct,

day = "1",

language = "English",

volume = "34",

pages = "5357--5362",

journal = "Anticancer research",

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TY - JOUR

T1 - Prognostic significance of High Mobility Group Box 1 (HMGB1) expression in patients with colorectal cancer

AU - Ueda, Masami

AU - Takahashi, Yusuke

AU - Shinden, Yoshiaki

AU - Sakimura, Shotaro

AU - Hirata, Hidenari

AU - Uchi, Ryutaro

AU - Takano, Yuki

AU - Kurashige, Junji

AU - Iguchi, Tomohiro

AU - Eguchi, Hidetoshi

AU - Sugimachi, Keishi

AU - Yamamoto, Hirofumi

AU - Doki, Yuichiro

AU - Mori, Masaki

AU - Mimori, Koshi

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Background: High mobility group 1 (HMGB1) is a highly conserved non-histone nucleosomal protein in mammals. We investigated the clinical significance of HMGB1 expression in colorectal cancer (CRC). Patients and Methods: The expression of HMGB1 mRNA in 140 tumor and normal tissues from CRC patients was examined by quantitative real-time polymerase chain reaction (PCR). We immunohistochemically investigated HMGB1 expression in tumor and metastatic lymph nodes in CRC. Results: HMGB1 expression was significantly higher in tumor than in normal tissues. High HMGB1 expression was associated with larger tumor volumes, higher rates of lymphatic invasion, more frequent lymph node metastases and poorer prognoses for overall survival. Multivariate analyses showed that HMGB1 expression was an independent prognostic indicator of overall survival. Immunocytochemical analysis revealed that HMGB1 was overexpressed in both CRC tissues and regional lymph node metastases. Conclusion: Investigating HMGB1 expression may be a predictor of postoperative lymph node metastasis and prognosis in CRC.

AB - Background: High mobility group 1 (HMGB1) is a highly conserved non-histone nucleosomal protein in mammals. We investigated the clinical significance of HMGB1 expression in colorectal cancer (CRC). Patients and Methods: The expression of HMGB1 mRNA in 140 tumor and normal tissues from CRC patients was examined by quantitative real-time polymerase chain reaction (PCR). We immunohistochemically investigated HMGB1 expression in tumor and metastatic lymph nodes in CRC. Results: HMGB1 expression was significantly higher in tumor than in normal tissues. High HMGB1 expression was associated with larger tumor volumes, higher rates of lymphatic invasion, more frequent lymph node metastases and poorer prognoses for overall survival. Multivariate analyses showed that HMGB1 expression was an independent prognostic indicator of overall survival. Immunocytochemical analysis revealed that HMGB1 was overexpressed in both CRC tissues and regional lymph node metastases. Conclusion: Investigating HMGB1 expression may be a predictor of postoperative lymph node metastasis and prognosis in CRC.

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AN - SCOPUS:84917692655

SN - 0250-7005

VL - 34

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JO - Anticancer research

JF - Anticancer research

IS - 10

ER -

Prognostic significance of High Mobility Group Box 1 (HMGB1) expression in patients with colorectal cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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