TY - JOUR
T1 - Prognostic nutritional index
T2 - A tool to predict the biological aggressiveness of gastric carcinoma
AU - Nozoe, Tadahiro
AU - Ninomiya, Mizuki
AU - Maeda, Takashi
AU - Matsukuma, Akito
AU - Nakashima, Hideaki
AU - Ezaki, Takahiro
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/5
Y1 - 2010/5
N2 - Purpose. The prognostic nutritional index (PNI), which is calculated based on the serum albumin concentration and the peripheral blood lymphocyte count, has been used to assess the immunological and nutritional condition of patients with digestive diseases. However, its value as an indicator of aggressiveness in gastric carcinoma has not been fully investigated. Methods. Two hundred and forty-eight cases of gastric carcinoma were studied with regard to the relationship between the preoperative PNI value and the clinicopathological characteristics of the patients. Results. A lower preoperative PNI value signifi cantly correlated with greater tumor depth, lymph node metastasis, lymphatic permeation, and venous invasion. Moreover, the PNI value proved to be an independent prognostic indicator in gastric carcinoma. Conclusion. The PNI value can be a useful tool to predict the prognosis of patients with gastric carcinoma.
AB - Purpose. The prognostic nutritional index (PNI), which is calculated based on the serum albumin concentration and the peripheral blood lymphocyte count, has been used to assess the immunological and nutritional condition of patients with digestive diseases. However, its value as an indicator of aggressiveness in gastric carcinoma has not been fully investigated. Methods. Two hundred and forty-eight cases of gastric carcinoma were studied with regard to the relationship between the preoperative PNI value and the clinicopathological characteristics of the patients. Results. A lower preoperative PNI value signifi cantly correlated with greater tumor depth, lymph node metastasis, lymphatic permeation, and venous invasion. Moreover, the PNI value proved to be an independent prognostic indicator in gastric carcinoma. Conclusion. The PNI value can be a useful tool to predict the prognosis of patients with gastric carcinoma.
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U2 - 10.1007/s00595-009-4065-y
DO - 10.1007/s00595-009-4065-y
M3 - Article
C2 - 20425547
AN - SCOPUS:77955688447
SN - 0941-1291
VL - 40
SP - 440
EP - 443
JO - Surgery today
JF - Surgery today
IS - 5
ER -