Prognostic markers for immunochemotherapy using tegafur -uracil (UFT) and protein-bound polysaccharide K (PSK).

Keiji Yoshinaga; Hiroshi Saeki; Eiji Oki; Masaru Morita; Tetsuo Ikeda; Keishi Sugimachi; Yo Ichi Yamashita; Toru Ikegami; Hideaki Uchiyama; Tomoharu Yoshizumi; Yuji Soejima; Hirofumi Kawanaka; Koshi Mimori; Masayuki Watanabe; Yoshihiko Maehara

Prognostic markers for immunochemotherapy using tegafur -uracil (UFT) and protein-bound polysaccharide K (PSK).

Keiji Yoshinaga, Hiroshi Saeki, Eiji Oki, Masaru Morita, Tetsuo Ikeda, Keishi Sugimachi, Yo Ichi Yamashita, Toru Ikegami, Hideaki Uchiyama, Tomoharu Yoshizumi, Yuji Soejima, Hirofumi Kawanaka, Koshi Mimori, Masayuki Watanabe, Yoshihiko Maehara

Research output: Contribution to journal › Article › peer-review

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Abstract

We previously reported that PSK-induced lymphocyte blastogenesis reaction (PSK-stimulation index; PSK-SI) may be a prognostic marker for immunochemotherapy using PSK in gastrointestinal cancer patients. In this study we evaluated the usefulness of PSK-SI as a prognostic marker for PSK therapy at higher and lower serum immunosuppressive acidic protein (IAP) levels. 98 gastric and 135 colorectal cancer patients were analyzed. PSK-SI and serum IAP levels were measured preoperatively. After operation, patients received UFT and PSK for two years. There were no differences between patients with higher and those with lower PSK-SI with respect to the clinicopathological factors. In patients with higher serum IAP levels (> or = 500 microg/ml), recurrence-free survival (RFS) and overall survival (OS) were apparently more favorable in the higher PSK-SI group (gastric cancer; > or = 1.75, colorectal cancer; > or = 2.1) than in lower PSK-SI group, although the differences were not significant. Serum IAP levels and PSK-SI may be useful markers for prediction of response to immunochemotherapy using PSK, although further studies are necessary.

Original language	English
Pages (from-to)	549-558
Number of pages	10
Journal	Fukuoka igaku zasshi = Hukuoka acta medica
Volume	104
Issue number	12
Publication status	Published - Dec 2013

All Science Journal Classification (ASJC) codes

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Yoshinaga, K., Saeki, H., Oki, E., Morita, M., Ikeda, T., Sugimachi, K., Yamashita, Y. I., Ikegami, T., Uchiyama, H., Yoshizumi, T., Soejima, Y., Kawanaka, H., Mimori, K., Watanabe, M., & Maehara, Y. (2013). Prognostic markers for immunochemotherapy using tegafur -uracil (UFT) and protein-bound polysaccharide K (PSK). Fukuoka igaku zasshi = Hukuoka acta medica, 104(12), 549-558.

Yoshinaga, K, Saeki, H, Oki, E, Morita, M, Ikeda, T, Sugimachi, K, Yamashita, YI, Ikegami, T, Uchiyama, H, Yoshizumi, T, Soejima, Y, Kawanaka, H, Mimori, K, Watanabe, M & Maehara, Y 2013, 'Prognostic markers for immunochemotherapy using tegafur -uracil (UFT) and protein-bound polysaccharide K (PSK).', Fukuoka igaku zasshi = Hukuoka acta medica, vol. 104, no. 12, pp. 549-558.

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title = "Prognostic markers for immunochemotherapy using tegafur -uracil (UFT) and protein-bound polysaccharide K (PSK).",

abstract = "We previously reported that PSK-induced lymphocyte blastogenesis reaction (PSK-stimulation index; PSK-SI) may be a prognostic marker for immunochemotherapy using PSK in gastrointestinal cancer patients. In this study we evaluated the usefulness of PSK-SI as a prognostic marker for PSK therapy at higher and lower serum immunosuppressive acidic protein (IAP) levels. 98 gastric and 135 colorectal cancer patients were analyzed. PSK-SI and serum IAP levels were measured preoperatively. After operation, patients received UFT and PSK for two years. There were no differences between patients with higher and those with lower PSK-SI with respect to the clinicopathological factors. In patients with higher serum IAP levels (> or = 500 microg/ml), recurrence-free survival (RFS) and overall survival (OS) were apparently more favorable in the higher PSK-SI group (gastric cancer; > or = 1.75, colorectal cancer; > or = 2.1) than in lower PSK-SI group, although the differences were not significant. Serum IAP levels and PSK-SI may be useful markers for prediction of response to immunochemotherapy using PSK, although further studies are necessary.",

author = "Keiji Yoshinaga and Hiroshi Saeki and Eiji Oki and Masaru Morita and Tetsuo Ikeda and Keishi Sugimachi and Yamashita, {Yo Ichi} and Toru Ikegami and Hideaki Uchiyama and Tomoharu Yoshizumi and Yuji Soejima and Hirofumi Kawanaka and Koshi Mimori and Masayuki Watanabe and Yoshihiko Maehara",

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language = "English",

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T1 - Prognostic markers for immunochemotherapy using tegafur -uracil (UFT) and protein-bound polysaccharide K (PSK).

AU - Yoshinaga, Keiji

AU - Saeki, Hiroshi

AU - Oki, Eiji

AU - Morita, Masaru

AU - Ikeda, Tetsuo

AU - Sugimachi, Keishi

AU - Yamashita, Yo Ichi

AU - Ikegami, Toru

AU - Uchiyama, Hideaki

AU - Yoshizumi, Tomoharu

AU - Soejima, Yuji

AU - Kawanaka, Hirofumi

AU - Mimori, Koshi

AU - Watanabe, Masayuki

AU - Maehara, Yoshihiko

PY - 2013/12

Y1 - 2013/12

N2 - We previously reported that PSK-induced lymphocyte blastogenesis reaction (PSK-stimulation index; PSK-SI) may be a prognostic marker for immunochemotherapy using PSK in gastrointestinal cancer patients. In this study we evaluated the usefulness of PSK-SI as a prognostic marker for PSK therapy at higher and lower serum immunosuppressive acidic protein (IAP) levels. 98 gastric and 135 colorectal cancer patients were analyzed. PSK-SI and serum IAP levels were measured preoperatively. After operation, patients received UFT and PSK for two years. There were no differences between patients with higher and those with lower PSK-SI with respect to the clinicopathological factors. In patients with higher serum IAP levels (> or = 500 microg/ml), recurrence-free survival (RFS) and overall survival (OS) were apparently more favorable in the higher PSK-SI group (gastric cancer; > or = 1.75, colorectal cancer; > or = 2.1) than in lower PSK-SI group, although the differences were not significant. Serum IAP levels and PSK-SI may be useful markers for prediction of response to immunochemotherapy using PSK, although further studies are necessary.

AB - We previously reported that PSK-induced lymphocyte blastogenesis reaction (PSK-stimulation index; PSK-SI) may be a prognostic marker for immunochemotherapy using PSK in gastrointestinal cancer patients. In this study we evaluated the usefulness of PSK-SI as a prognostic marker for PSK therapy at higher and lower serum immunosuppressive acidic protein (IAP) levels. 98 gastric and 135 colorectal cancer patients were analyzed. PSK-SI and serum IAP levels were measured preoperatively. After operation, patients received UFT and PSK for two years. There were no differences between patients with higher and those with lower PSK-SI with respect to the clinicopathological factors. In patients with higher serum IAP levels (> or = 500 microg/ml), recurrence-free survival (RFS) and overall survival (OS) were apparently more favorable in the higher PSK-SI group (gastric cancer; > or = 1.75, colorectal cancer; > or = 2.1) than in lower PSK-SI group, although the differences were not significant. Serum IAP levels and PSK-SI may be useful markers for prediction of response to immunochemotherapy using PSK, although further studies are necessary.

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Prognostic markers for immunochemotherapy using tegafur -uracil (UFT) and protein-bound polysaccharide K (PSK).

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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