Prognostic impact of tissue inhibitor of matrix metalloproteinase-1 in esophageal carcinoma

Masaki Mori, Koshi Mimori, Noriaki Sadanaga, Hiroshi Inoue, Yoichi Tanaka, Ken Ichi Mafune, Hiroaki Ueo, Graham F. Barnard

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Tissue inhibitor of metalloproteinase-1 (TIMP-1) inhibits the activity of matrix metalloproteinase, which may play an important role in carcinoma invasion and metastasis. TIMP-1 is thus considered to inhibit carcinoma invasion and metastasis. However, TIMP-1 possesses another important function, cell growth promotion. The clinical significance of TIMP-1 expression has not been fully determined in esophageal carcinoma. We thus examined the expression of TIMP-1 mRNA in tumor (T) and corresponding normal (N) tissues of 85 esophageal carcinoma cases by RT-PCR. The T:N ratio of TIMP-1 mRNA expression in each case was evaluated semiquantitatively with adjustment by an internal control gene. The mean T:N ratio was 2.0 (range 0.2-6.5). When comparing high-expression cases (T:N > 2.0, n = 37) with low-expression cases (T:N ≤ 2.0, n = 48), the former showed a significantly higher frequency of lymph vessel invasion, vascular vessel invasion, lymph node metastasis and advanced-stage disease. The former cases showed a poorer prognosis than the latter. Multivariate analysis disclosed that TIMP-1 expression status was an independent determining factor for prognosis. Our findings suggest that TIMP-1 expression correlates with tumor extension of esophageal carcinoma and might, if validated, prove useful as a novel prognostic marker for esophageal carcinoma. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)575-578
Number of pages4
JournalInternational Journal of Cancer
Issue number4
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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