TY - JOUR
T1 - Prognostic impact of albumin-bilirubin (ALBI) grade on non-small lung cell carcinoma
T2 - A propensity-score matched analysis
AU - Kinoshita, Fumihiko
AU - Yamashita, Takanori
AU - Oku, Yuka
AU - Kosai, Keisuke
AU - Ono, Yuki
AU - Wakasu, Sho
AU - Haratake, Naoki
AU - Toyokawa, Gouji
AU - Takenaka, Tomoyoshi
AU - Tagawa, Tetsuzo
AU - Shimokawa, Mototsugu
AU - Nakashima, Naoki
AU - Mori, Masaki
N1 - Funding Information:
The Authors thank Takashi Kinoshita from the Medical Information Center, Kyushu University Hospital, for invaluable help with data collection. The Authors also thank Mark Abramovitz, PhD, from Edanz Group (https://en-author-services.edanzgroup.com/ac) for editing a draft of this manuscript.
Publisher Copyright:
© 2021 International Institute of Anticancer Research. All rights reserved.
PY - 2021/3
Y1 - 2021/3
N2 - Background/Aim: Albumin-bilirubin (ALBI) grade is an indicator of liver dysfunction and is useful for predicting postoperative prognosis of hepatocellular carcinomas. However, the significance of ALBI grade in non-small cell lung carcinoma (NSCLC) has not been elucidated. Patients and Methods: We analyzed 947 patients with pStage IA-IIIA NSCLC. We divided patients into ALBI grade 1 and grade 2/3 groups. We then analyzed the association of ABLI grade with clinicopathological characteristics and prognosis in NSCLC by using propensity-score matching. Results: ALBI grade 2/3 was significantly associated with older age, male sex, advanced pT status, and histological type. Even after propensity-score matching, ALBI grade 2/3 patients had significantly worse cancer-specific survival (CSS) than ALBI grade 1 patients (5-year CSS: 87.3% versus 92.8%; p=0.0247). In multivariate analysis, ALBI grade 2/3 was an independent predictor of CSS (HR=1.9; 95%CI=1.11-3.11; p=0.0177). Conclusion: ALBI grade was an independent prognostic factor in surgically resected NSCLC.
AB - Background/Aim: Albumin-bilirubin (ALBI) grade is an indicator of liver dysfunction and is useful for predicting postoperative prognosis of hepatocellular carcinomas. However, the significance of ALBI grade in non-small cell lung carcinoma (NSCLC) has not been elucidated. Patients and Methods: We analyzed 947 patients with pStage IA-IIIA NSCLC. We divided patients into ALBI grade 1 and grade 2/3 groups. We then analyzed the association of ABLI grade with clinicopathological characteristics and prognosis in NSCLC by using propensity-score matching. Results: ALBI grade 2/3 was significantly associated with older age, male sex, advanced pT status, and histological type. Even after propensity-score matching, ALBI grade 2/3 patients had significantly worse cancer-specific survival (CSS) than ALBI grade 1 patients (5-year CSS: 87.3% versus 92.8%; p=0.0247). In multivariate analysis, ALBI grade 2/3 was an independent predictor of CSS (HR=1.9; 95%CI=1.11-3.11; p=0.0177). Conclusion: ALBI grade was an independent prognostic factor in surgically resected NSCLC.
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U2 - 10.21873/anticanres.14924
DO - 10.21873/anticanres.14924
M3 - Article
C2 - 33788758
AN - SCOPUS:85103173323
SN - 0250-7005
VL - 41
SP - 1621
EP - 1628
JO - Anticancer research
JF - Anticancer research
IS - 3
ER -
