Prognosis of early-stage part-solid and pure-solid lung adenocarcinomas

Fumio Kinoshita; Gouji Toyokawa; Taichi Matsubara; Yuka Kozuma; Naoki Haratake; Shinkichi Takamori; Takaki Akamine; Fumihiko Hirai; Tomoyoshi Takenaka; Tetsuzo Tagawa; Yoshihiko Maehara

doi:10.21873/anticanres.13391

Prognosis of early-stage part-solid and pure-solid lung adenocarcinomas

Fumio Kinoshita, Gouji Toyokawa, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Fumihiko Hirai, Tomoyoshi Takenaka, Tetsuzo Tagawa, Yoshihiko Maehara

Chest Surgery (2)

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Abstract

Background/Aim: In the new TNM classification (8th edition) of lung cancer, T category is defined based on the solid component size; therefore, part solid type (PST) with and solid type (ST) without ground glass opacity (GGO) are categorized as same T value according to their solid component sizes. However, differences between these tumors have not been clarified. Patients and Methods The study included 274 pStage I lung adenocarcinoma patients who had undergone surgery at our Institution from 2003 to 2012. Their tumors were classified as pure GGO, PST, and ST. After propensity score matching for solid component size, we compared prognoses between PST and ST. Results: The same percentage was noted for PST and ST tumors (119/274; 43.4%). After propensity score matching, the disease-free survival (DFS) was significantly worse in ST than PST (5-year DFS: 69.2% versus 88.7%; p=0.0241). Conclusion: Prognoses of PST and ST adenocarcinomas differ even when their solid component sizes are the same.

Original language	English
Pages (from-to)	2665-2670
Number of pages	6
Journal	Anticancer research
Volume	39
Issue number	5
DOIs	https://doi.org/10.21873/anticanres.13391
Publication status	Published - May 2019

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.13391

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title = "Prognosis of early-stage part-solid and pure-solid lung adenocarcinomas",

abstract = "Background/Aim: In the new TNM classification (8th edition) of lung cancer, T category is defined based on the solid component size; therefore, part solid type (PST) with and solid type (ST) without ground glass opacity (GGO) are categorized as same T value according to their solid component sizes. However, differences between these tumors have not been clarified. Patients and Methods The study included 274 pStage I lung adenocarcinoma patients who had undergone surgery at our Institution from 2003 to 2012. Their tumors were classified as pure GGO, PST, and ST. After propensity score matching for solid component size, we compared prognoses between PST and ST. Results: The same percentage was noted for PST and ST tumors (119/274; 43.4%). After propensity score matching, the disease-free survival (DFS) was significantly worse in ST than PST (5-year DFS: 69.2% versus 88.7%; p=0.0241). Conclusion: Prognoses of PST and ST adenocarcinomas differ even when their solid component sizes are the same.",

author = "Fumio Kinoshita and Gouji Toyokawa and Taichi Matsubara and Yuka Kozuma and Naoki Haratake and Shinkichi Takamori and Takaki Akamine and Fumihiko Hirai and Tomoyoshi Takenaka and Tetsuzo Tagawa and Yoshihiko Maehara",

year = "2019",

month = may,

doi = "10.21873/anticanres.13391",

language = "English",

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pages = "2665--2670",

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T1 - Prognosis of early-stage part-solid and pure-solid lung adenocarcinomas

AU - Kinoshita, Fumio

AU - Toyokawa, Gouji

AU - Matsubara, Taichi

AU - Kozuma, Yuka

AU - Haratake, Naoki

AU - Takamori, Shinkichi

AU - Akamine, Takaki

AU - Hirai, Fumihiko

AU - Takenaka, Tomoyoshi

AU - Tagawa, Tetsuzo

AU - Maehara, Yoshihiko

PY - 2019/5

Y1 - 2019/5

N2 - Background/Aim: In the new TNM classification (8th edition) of lung cancer, T category is defined based on the solid component size; therefore, part solid type (PST) with and solid type (ST) without ground glass opacity (GGO) are categorized as same T value according to their solid component sizes. However, differences between these tumors have not been clarified. Patients and Methods The study included 274 pStage I lung adenocarcinoma patients who had undergone surgery at our Institution from 2003 to 2012. Their tumors were classified as pure GGO, PST, and ST. After propensity score matching for solid component size, we compared prognoses between PST and ST. Results: The same percentage was noted for PST and ST tumors (119/274; 43.4%). After propensity score matching, the disease-free survival (DFS) was significantly worse in ST than PST (5-year DFS: 69.2% versus 88.7%; p=0.0241). Conclusion: Prognoses of PST and ST adenocarcinomas differ even when their solid component sizes are the same.

AB - Background/Aim: In the new TNM classification (8th edition) of lung cancer, T category is defined based on the solid component size; therefore, part solid type (PST) with and solid type (ST) without ground glass opacity (GGO) are categorized as same T value according to their solid component sizes. However, differences between these tumors have not been clarified. Patients and Methods The study included 274 pStage I lung adenocarcinoma patients who had undergone surgery at our Institution from 2003 to 2012. Their tumors were classified as pure GGO, PST, and ST. After propensity score matching for solid component size, we compared prognoses between PST and ST. Results: The same percentage was noted for PST and ST tumors (119/274; 43.4%). After propensity score matching, the disease-free survival (DFS) was significantly worse in ST than PST (5-year DFS: 69.2% versus 88.7%; p=0.0241). Conclusion: Prognoses of PST and ST adenocarcinomas differ even when their solid component sizes are the same.

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Prognosis of early-stage part-solid and pure-solid lung adenocarcinomas

Abstract

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UN SDGs

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