Production of daunorubicin by immobilized growing Streptomyces peucetius cells

Yoshiki Takashima, Hiroki Nakajima, Kenji Sonomoto, Atsuo Tanaka

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14 Citations (Scopus)


Streptomyces peucetius cells were immobilized by entrapment in calcium alginate and a photosensitive synthetic polymer, and used for the production of daunorubicin (daunomycin), which is known to be an antitumour reagent. The use of cultivation media removed insoluble components in a natural medium prevented rapid decrease in daunorubicin titer after maximum production. These entrapped cells could be used at least five times for repeated daunorubicin production; the total cultivation period was 45 days.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalApplied Microbiology and Biotechnology
Issue number2
Publication statusPublished - Nov 1 1987

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology


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