Production of daunorubicin by immobilized growing Streptomyces peucetius cells

Yoshiki Takashima; Hiroki Nakajima; Kenji Sonomoto; Atsuo Tanaka

doi:10.1007/BF00251930

Production of daunorubicin by immobilized growing Streptomyces peucetius cells

Yoshiki Takashima, Hiroki Nakajima, Kenji Sonomoto, Atsuo Tanaka

Systems Biology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Streptomyces peucetius cells were immobilized by entrapment in calcium alginate and a photosensitive synthetic polymer, and used for the production of daunorubicin (daunomycin), which is known to be an antitumour reagent. The use of cultivation media removed insoluble components in a natural medium prevented rapid decrease in daunorubicin titer after maximum production. These entrapped cells could be used at least five times for repeated daunorubicin production; the total cultivation period was 45 days.

Original language	English
Pages (from-to)	106-109
Number of pages	4
Journal	Applied Microbiology and Biotechnology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1007/BF00251930
Publication status	Published - Nov 1 1987

All Science Journal Classification (ASJC) codes

Biotechnology
Applied Microbiology and Biotechnology

Access to Document

10.1007/BF00251930

Cite this

@article{147ead6f8ee6494eb2dfe81b2a8312cd,

title = "Production of daunorubicin by immobilized growing Streptomyces peucetius cells",

abstract = "Streptomyces peucetius cells were immobilized by entrapment in calcium alginate and a photosensitive synthetic polymer, and used for the production of daunorubicin (daunomycin), which is known to be an antitumour reagent. The use of cultivation media removed insoluble components in a natural medium prevented rapid decrease in daunorubicin titer after maximum production. These entrapped cells could be used at least five times for repeated daunorubicin production; the total cultivation period was 45 days.",

author = "Yoshiki Takashima and Hiroki Nakajima and Kenji Sonomoto and Atsuo Tanaka",

year = "1987",

month = nov,

day = "1",

doi = "10.1007/BF00251930",

language = "English",

volume = "27",

pages = "106--109",

journal = "Applied Microbiology and Biotechnology",

issn = "0175-7598",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - Production of daunorubicin by immobilized growing Streptomyces peucetius cells

AU - Takashima, Yoshiki

AU - Nakajima, Hiroki

AU - Sonomoto, Kenji

AU - Tanaka, Atsuo

PY - 1987/11/1

Y1 - 1987/11/1

N2 - Streptomyces peucetius cells were immobilized by entrapment in calcium alginate and a photosensitive synthetic polymer, and used for the production of daunorubicin (daunomycin), which is known to be an antitumour reagent. The use of cultivation media removed insoluble components in a natural medium prevented rapid decrease in daunorubicin titer after maximum production. These entrapped cells could be used at least five times for repeated daunorubicin production; the total cultivation period was 45 days.

AB - Streptomyces peucetius cells were immobilized by entrapment in calcium alginate and a photosensitive synthetic polymer, and used for the production of daunorubicin (daunomycin), which is known to be an antitumour reagent. The use of cultivation media removed insoluble components in a natural medium prevented rapid decrease in daunorubicin titer after maximum production. These entrapped cells could be used at least five times for repeated daunorubicin production; the total cultivation period was 45 days.

UR - http://www.scopus.com/inward/record.url?scp=0023553645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023553645&partnerID=8YFLogxK

U2 - 10.1007/BF00251930

DO - 10.1007/BF00251930

M3 - Article

AN - SCOPUS:0023553645

SN - 0175-7598

VL - 27

SP - 106

EP - 109

JO - Applied Microbiology and Biotechnology

JF - Applied Microbiology and Biotechnology

IS - 2

ER -

Production of daunorubicin by immobilized growing Streptomyces peucetius cells

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this